II. Interpretation
- Normal: <1.0 mg/dl
III. Causes: Increased (Unconjugated Hyperbilirubinemia)
- Increased Bilirubin production
- Hemolytic Anemia (typically mild Hyperbilirubinemia)
- Large heme load (e.g. large Hematoma reabsorption)
- Rhabdomyolysis
- Hyperthyroidism (Thyrotoxicosis)
- Ineffective Erythropoiesis (increased RBC destruction in marrow)
- Thalassemia
- Pernicious Anemia
- Sickle Cell Anemia
- Lead Poisoning
- Iron Deficiency Anemia
- Myeloproliferative Disorder
- Defective Bilirubin conjugation
- Neonatal Jaundice (immature liver)
- Gilbert's disease
- Crigler-Najjar syndrome
- Impaired hepatic uptake of Bilirubin
- Medications (e.g. Gemfibrozil, Indinavir)
- Portosystemic shunt
- Hepatic congestion (e.g .CHF, liver disease)