II. Physiology
- Transport Proteins aid in substance transfer in and out of the cell
III. Pathophysiology
- Transport Proteins may interfere with drug absorption, distribution and elimination
IV. Types
- Breast Cancer Resistance Protein (BCRP)
- Organic Anion Transport Protein (e.g. OATP1B1, OATP1B3)
- Organic Cation Transport Protein (e.g. OCT2)
- Multidrug and Toxin Exctrusion Protein (e.g. MATE1, MAE2-K)
V. References
- (2022) presc lett 29(8): 47-8
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| Definition (MSH) | Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS. |
| Definition (CSP) | diverse family of membrane proteins which catalyze the transfer of small, usually lipophobic solutes across the membrane; may mediate active (ATP-driven), co- (countergradient-driven), or passive transport. |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D026901 |
| Swedish | Membrantransportproteiner |
| English | membrane transport protein, Membrane Transport Proteins [Chemical/Ingredient], transporter, transporters, membrane transporter, membrane transport proteins, Membrane Transporters, Transport Proteins, Membrane, Transporters, Membrane, Membrane Transport Proteins |
| Czech | membránové transportní proteiny, membránové přenašeče |
| Finnish | Membraanikuljetusproteiinit |
| French | Protéines de transport membranaire, Transporteurs membranaires, Protéines de transport membranaires |
| Italian | Trasportatori di membrana, Proteine di trasporto della membrana |
| Russian | MEMBRANNOGO TRANSPORTA BELKI, BIOLOGICHESKII NASOS, MEMBRANNYE PERENOSCHIKI, METABOLICHESKII NASOS, MEMBRANNYE TRANSPORTERY, PERMEAZY, БИОЛОГИЧЕСКИЙ НАСОС, МЕМБРАННОГО ТРАНСПОРТА БЕЛКИ, МЕМБРАННЫЕ ПЕРЕНОСЧИКИ, МЕМБРАННЫЕ ТРАНСПОРТЕРЫ, МЕТАБОЛИЧЕСКИЙ НАСОС, ПЕРМЕАЗЫ |
| Japanese | ペルミアーゼ, ペルメアーゼ, 透過酵素, パーミアーゼ, 代謝ポンプ, 生物学的ポンプ, 膜輸送蛋白質 |
| Croatian | Not Translated[Membrane Transport Proteins] |
| Polish | Białka transportu błonowego |
| Norwegian | Not Translated[Membrane Transport Proteins] |
| German | Membran-Transporter, Membrantransportproteine |
| Portuguese | Transportadoras da Membrana, Proteínas de Membrana Transportadoras |
| Spanish | Transportadores de Membranas, Proteínas de Transporte de Membrana |
Ontology: Organic Cation Transport Proteins (C0949808)
| Definition (MSH) | A family of proteins involved in the transport of organic cations. They play an important role in the elimination of a variety of endogenous substances, xenobiotics, and their metabolites from the body. |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D027701 |
| Swedish | Organiska anjontransportproteiner |
| English | MEMBRANE TRANSPORT PROTEINS CATION ORGANIC, Organic Cation Transport Proteins [Chemical/Ingredient], Membrane Transport-Proteins, Organic Cation, Organic Cation Transport Proteins |
| Czech | proteiny přenášející organické kationty |
| Finnish | Orgaanisten kationien kuljettajaproteiinit |
| Russian | MEMBRANNYE TRANSPORTNYE BELKI ORGANICHESKIKH KATIONOV, ORGANICHESKIKH KATIONOV TRANSPORTNYE BELKI, KATIONOV ORGANICHESKIKH TRANSPORTA BELKI, КАТИОНОВ ОРГАНИЧЕСКИХ ТРАНСПОРТА БЕЛКИ, МЕМБРАННЫЕ ТРАНСПОРТНЫЕ БЕЛКИ ОРГАНИЧЕСКИХ КАТИОНОВ, ОРГАНИЧЕСКИХ КАТИОНОВ ТРАНСПОРТНЫЕ БЕЛКИ |
| Japanese | 膜輸送蛋白質-有機陽イオン, カチオントランスポーター-有機, 陽イオン輸送蛋白質-有機, 有機陽イオントランスポーター, カチオン輸送蛋白質-有機, 有機カチオン輸送蛋白質, 有機陽イオン輸送体, 有機陽イオン輸送蛋白質, 膜輸送蛋白質-有機カチオン, 有機カチオントランスポーター |
| French | Protéines de transport de cations organiques, Transporteurs de cations organiques |
| Italian | Proteine di trasporto della membrana dei cationi organici, Proteine di trasporto dei cationi organici |
| Polish | Białka transportu kationów organicznych |
| Spanish | Proteínas de Transporte de Cationes Orgánicos, Proteínas de Membrana Transportadoras de Catión Orgánico, Proteínas de Transporte de Catión Orgánico |
| Portuguese | Proteínas Transportadoras de Cátions Orgânicos, Proteínas de Membrana Transportadoras de Cátions Orgânicos, Proteínas de Transporte de Cátions Orgânicos |
| German | Membrantransportproteine für organische Kationen, Transportproteine für organische Kationen |
Ontology: Organic Anion Transporters (C0969703)
| Definition (MSH) | Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body. |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D027361 |
| Swedish | Organiska anjontransportörer |
| English | MEMBRANE TRANSPORT PROTEINS ANION ORGANIC, Organic Anion Transporters [Chemical/Ingredient], Anion Transporters, Organic, Membrane Transport Proteins, Organic Anion, Organic Anion Transporters, Transporters, Organic Anion |
| Czech | transportéry organických aniontů, přenašeče organických aniontů, membránové proteiny přenášející organické anionty |
| Finnish | Orgaanisten anionien kuljettajat |
| Russian | ORGANICHESKIKH ANIONOV TRANSPORTERY, MEMBRANNYE TRANSPORTNYE BELKI ORGANICHESKIKH ANIONOV, BELKI MEMBRANNOGO TRANSPORTA ORGANICHESKIKH ANIONOV, ANIONOV ORGANICHESKIKH PERENOSCHIKI, ORGANICHESKIKH ANIONOV TRANSPORTNYE POLIPEPTIDY, АНИОНОВ ОРГАНИЧЕСКИХ ПЕРЕНОСЧИКИ, БЕЛКИ МЕМБРАННОГО ТРАНСПОРТА ОРГАНИЧЕСКИХ АНИОНОВ, МЕМБРАННЫЕ ТРАНСПОРТНЫЕ БЕЛКИ ОРГАНИЧЕСКИХ АНИОНОВ, ОРГАНИЧЕСКИХ АНИОНОВ ТРАНСПОРТЕРЫ, ОРГАНИЧЕСКИХ АНИОНОВ ТРАНСПОРТНЫЕ ПОЛИПЕПТИДЫ |
| Japanese | 有機アニオン輸送ポリペプチド, 陰イオン輸送蛋白質-有機, 有機アニオン輸送体, 有機陰イオン輸送体, アニオントランスポーター-有機, 陰イオントランスポーター-有機, 有機アニオン輸送担体, 有機陰イオントランスポーター, 膜輸送蛋白質-有機アニオン, 有機アニオントランスポーター |
| French | Transporteurs des anions organiques, Transporteurs d'anions organiques |
| Croatian | Not Translated[Organic Anion Transporters] |
| Polish | Przenośniki anionów organicznych |
| Portuguese | Proteínas da Membrana Transportadoras de Ânions Orgânicos, Proteínas da Membrana de Transporte de Ânions Orgânicos, Transportadores de Ânions Orgânicos |
| German | Membrantransportproteine, organische Anionen, Transporter für organische Anionen |
| Italian | Trasportatori di anioni organici |
| Spanish | Proteínas de Transporte de Membrana de Anión Orgánico, Transportadores de Anión Orgánico |
