II. Causes: Decreased renal excretion

  1. Hypoaldosteronism
    1. Hyporeninemic hypoaldosteronism
      1. Intrinsic renal disease (provoked by dehydration)
        1. Type IV Renal Tubular Acidosis
        2. Diabetes Mellitus (esp. Diabetic Nephropathy)
        3. Interstitial Nephritis
      2. Prostaglandin synthetase inhibitors
    2. Primary Hypoaldosteronism
    3. Medication-induced hypoaldosteronism
      1. See medications below
    4. Adrenal Insufficiency (volume low, decreased GFR)
  2. Decreased distal renal flow
    1. Renal Insufficiency or Renal Failure
      1. Acute Kidney Injury
      2. Chronic Kidney Disease
    2. Congestive Heart Failure
    3. Congestive Heart Failure
      1. Decreased distal nephron Sodium delivery
  3. Primary tubular defects
    1. Renal Tubular Acidosis (Type 4)
    2. Obstructive uropathy
    3. Tubular unresponsiveness to aldosterone
      1. Systemic Lupus Erythematosus
      2. Multiple Myeloma
      3. Sickle Cell Anemia
  4. Medications
    1. Medication-induced hypoaldosteronism
      1. Heparin
      2. Cyclosporine
      3. ACE Inhibitor or Angiotensin Receptor Blocker
        1. Responsible for 50% of medication induced Hyperkalemia
        2. Concurrent trimethoprim-sulfamethoxazole increases risk (especially age>66)
        3. Risk of Hyperkalemia within the first year of starting ACE/ARB: 10%
        4. Raebel (2012) Cardiovasc Ther 30(3): e156-66 +PMID:21883995 [PubMed]
    2. Other medications
      1. Potassium sparing Diuretics (e.g. Spironolactone)
      2. NSAIDS
      3. Lithium
      4. Trimethoprim
      5. Calcineuron inhibitors (e.g. Tacrolimus)

III. Causes: Transcellular shift or redistribution (ICF to ECF)

  1. Metabolic Acidosis (more likely with mineral acids NH4, HCl)
  2. Hyperkalemic periodic paralysis
  3. Insulin deficiency or resistance (Diabetes Mellitus)
  4. Rapid ECF rise
    1. Hypertonic Glucose or mannitol infused
  5. Dialysis
  6. Coronary bypass
  7. Cell lysis
    1. Any significant cause of cell turnover releases significant Potassium
      1. 98% of body Potassium is intracellular
    2. Rhabdomyolysis
    3. Tissue necrosis, Burn Injury, crush injury, tumor lysis
    4. Massive Hemolysis
    5. Surgery
    6. Gastrointestinal Bleeding
    7. Red Blood Cell transfusion
  8. Hypertonicity (e.g. Hyperglycemia, mannitol)
  9. Medications
    1. Succinylcholine (if concurrent tissue damage)
    2. Beta Blockers
    3. Digitalis Intoxication (Digoxin Toxicity)
    4. Arginine
    5. Somatostatin

IV. Causes: Potassium load

  1. Oral or IV Potassium Supplementation
    1. See Foods with High Potassium Content
    2. Salt substitute
    3. Protein calorie supplements
  2. Blood Transfusion (RBC transfusion)
  3. High dose Penicillin G (1.7 meq K+ per 1 Million Units)

V. Causes: Pseudohyperkalemia (Actual Serum Potassium less than lab)

  1. Blood sample clotted or cooled
  2. Delayed analysis or other lab error
  3. Familial Pseudohyperkalemia
  4. Hemolysis
    1. Excessive Tourniquet or fist clenched repeatedly
    2. Hemolysis via small needle or Traumatic venipuncture
  5. Severe blood cell hyperplasia
    1. Severe Thrombocytosis
    2. Severe Leukocytosis (>75,000/mm3)

VI. References

  1. Gibbs in Marx (2002) Rosen's Emerg Med, p. 1730-1
  2. Klahr (2001) in Noble (2001) Primary Care p. 1359-62
  3. Viera (2015) Am Fam Physician 92(6): 487-95 [PubMed]

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Ontology: Potassium intoxication (C0268021)

Concepts Disease or Syndrome (T047)
SnomedCT 91466008
English Potassium intoxication, Potassium intoxication (disorder), potassium intoxication, intoxication; potassium, potassium intoxication; syndrome, potassium; intoxication, syndrome; potassium intoxication, K intoxication
Dutch intoxicatie; kalium, kalium; intoxicatie, kaliumintoxicatie; syndroom, syndroom; kaliumintoxicatie
Spanish intoxicación por potasio (trastorno), intoxicación por potasio

Ontology: Hyperkalemia, diminished renal excretion (C0268024)

Concepts Pathologic Function (T046)
SnomedCT 54781007
Spanish hipercalemia, reducción de la excreción renal, hiperkalemia, reducción de la excreción renal, hipocaluria, hipercaliemia, reducción de la excreción renal (trastorno), hipercaliemia, reducción de la excreción renal, hiperpotasemia, reducción de la excreción renal
English Hyperkalemia, diminished renal excretion, Hypokaluria, Hyperkalaemia, diminished renal excretion, Hyperkalemia, diminished renal excretion (disorder)

Ontology: Hyperkalemia, transcellular shifts (C0268025)

Concepts Pathologic Function (T046)
SnomedCT 5354002
Spanish hipercalemia, desplazamientos transcelulares, hiperkalemia, desplazamientos transcelulares, hipercaliemia, cambios transcelulares (trastorno), hipercaliemia, cambios transcelulares, hiperpotasemia, desplazamientos transcelulares
English Hyperkalemia, transcellular shifts, Hyperkalaemia, transcellular shifts, Hyperkalemia, transcellular shifts (disorder)

Ontology: Pseudohyperkalaemia (C0948309)

Concepts Pathologic Function (T046)
Italian Pseudoiperkaliemia
French Pseudohyperkalémie, Pseudohyperkaliémie
German Pseudohyperkalemia, Pseudohyperkalaemia
Portuguese Pseudo-hipercaliemia, Pseudohipercalemia
Japanese 偽高カリウム血症, ギコウカリウムケッショウ, ギコウカリウムケツショウ
English pseudohyperkalemia (diagnosis), pseudohyperkalemia, Pseudohyperkalaemia, Pseudohyperkalemia
Czech Pseudohyperkalemie
Hungarian Pseudohyperkalaemia
Spanish Seudohipercalemia
Dutch pseudohyperkaliëmie