II. Physiology
- Polypeptide secreted by the gastric mucosa
- Increases secretion of Stomach digestive substances
- Gastric acid
- Pepsin
- Intrinsic Factor
- Factors that increase Gastrin
- Vagus Nerve Stimulation
- Duodenal Distention
- Peptides within Stomach
- Factor that decrease Gastrin
- Secretin
- Gastric inhibitory peptide
- Increased Stomach acidity (low pH)
III. Labs
- Normal Serum Gastrin: <180 pg/ml
IV. Causes: Increased - Most important causes
- Medications (most common cause)
- Proton Pump Inhibitors (e.g. Omeprazole)
- Associated with 2-5 fold increase in Gastrin level
- H2 Blockers
- Proton Pump Inhibitors (e.g. Omeprazole)
-
Pernicious Anemia
- Very low Stomach acid level (contrast with Zollinger-Ellison)
- Zollinger-Ellison Syndrome or Gastrinoma (rare)
- Very high Gastrin level
- Gastrin Level remains increased despite withdrawal of Proton Pump Inhibitors and other possible causes
- High Stomach acid level
- Measured with nasogastric suction over one hour
- Contrast with very low Stomach acid level in Pernicious Anemia
V. Causes: Increased - Other Causes
- Hyperparathyroidism
- Retained gastric antrum
- Chronic atrophic Gastritis
- Pyloric obstruction
- Gastric neoplasm
- Chronic Renal Failure
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Related Studies
Definition (NCI_CDISC) | A measurement of the gastrin hormone in a biological specimen. |
Definition (NCI) | The determination of the amount of gastrin hormone present in a sample. |
Concepts | Laboratory Procedure (T059) |
SnomedCT | 87535006 |
CPT | 82941, 82938 |
English | Gastrin, Gastrin measurement, Gastrin Measurement, gastrin level test, Gastrin (GI tract hormone) level, Measurement of gastrin, ASSAY OF GASTRIN, GASTRIN, Gastrin level, Gastrin measurement (procedure), Assay of gastrin |
Dutch | gastrine |
French | Gastrine |
German | Gastrin |
Italian | Gastrina |
Portuguese | Gastrina |
Spanish | Gastrina, medición de gastrina (procedimiento), medición de gastrina |
Japanese | ガストリン, ガストリン |
Czech | Gastrin |
Hungarian | Gasztrin |