II. Indications
- Dyspepsia evaluation
- Confirmation of cure after H. Pylori Management
IV. Efficacy
-
Stool monoclonal Antigen tests (enzyme immunoassay)
- Test Sensitivity: 92-94%
- Test Specificity: 94-97%
- Likelihood: LR+ 24, LR- 0.7
- Most accurate, but more expensive than immunochromatography
-
Stool monoclonal Antigen tests (Immunochromatography, older methodology)
- Test Sensitivity: 69-87%
- Test Specificity: 87-93%
- Variable reliability, but available for office based testing
- Accurate for confirmation of cure at 7 days
- Antigen levels significantly suppressed with cure
- Vaira (2002) Ann Intern Med 136:280-7 [PubMed]
V. Protocol: Patient stops medications 2 weeks before test
- Stop Proton Pump Inhibitors (but less affected than Urea Breath Test)
- Stop all Antibiotics
- Stop bismuth compounds (e.g. Pepto Bismol)
VI. Advantages
- Excellent first line non-invasive test for diagnosis
- Noninvasive test of H. pylori cure
- Inexpensive