Definition (MSH)
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The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
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Definition (NCI)
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Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink)
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Definition (NCI_NCI-GLOSS)
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A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor.
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Definition (CSP)
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class of embryonic serum alpha globulins which appear in early development; in adult serum, the presence of AFP indicates certain pathologic states, especially liver neoplasms.
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Concepts |
Biologically Active Substance
(T123)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
D000509
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SnomedCT |
49944008, 59386002 |
LNC |
LP14331-0, MTHU027153 |
English |
alpha Fetoproteins, alpha-Fetoprotein, alpha-Fetoproteins, Fetuins, alpha fetoprotein, fetuin, alpha Foetoprotein, alpha-Fetoproteins [Chemical/Ingredient], alpha foetoprotein, alpha-fetoprotein (AFP), alpha fetoproteins, Alpha fetoproteins, alpha-fetoprotein, Alpha Fetoproteins, alpha Fetoprotein, Fetuin, AFP - Alpha-fetoprotein, Alpha-fetoprotein, Fetuin (substance), alpha Fetoprotein (substance), AFP, Alpha-1-Fetoprotein, Alpha-Fetoglobulin, Alpha-Fetoprotein |
German |
Alphafetoprotein, Alpha-Fetoprotein, AFP, Alpha-Fetoproteine |
Swedish |
Alfafetoproteiner
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Czech |
AFP, alfa-fetoproteiny |
Finnish |
Alfafetoproteiinit
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Russian |
AL'FA-FETOPROTEINY, AFP, АЛЬФА-ФЕТОПРОТЕИНЫ, АФП |
Japanese |
アルファフェトプロテイン, フェツイン, α-フェトプロテイン, アルファ胎児蛋白質, α-胎児性蛋白質, α-胎児性蛋白, フェチュイン, アルファ-胎児蛋白, アルファ-フェトプロテイン, フェトプロテイン |
Spanish |
alfa-Fetoproteínas, alfa fetoproteína (sustancia), alfa fetoproteína, fetoproteína alfa (sustancia), fetoproteína alfa, fetuína (sustancia), fetuína |
Croatian |
ALFA FETOPROTEINI
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French |
AFP (alpha-FoetoProtéine), Alphafoetoprotéines, Alphafoetoprotéine, alpha-Foetoprotéines |
Polish |
Alfa-fetoproteina
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Italian |
alfa-Fetoproteine
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Portuguese |
alfa-Fetoproteínas
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