II. Pathophysiology
- Membrane bound hepatic cell marker
- Suggests cholestasis
- Most sensitive, but least specific of all LFTs
III. Normal: 0-30 U/L
IV. Increased (Elevation 3 times normal is significant)
- Chronic Alcoholic Hepatitis or other liver disease
- Liver neoplasm or metastases
- Nephrotic Syndrome
- Cholestasis
- Pancreatic Carcinoma
- Congestive Heart Failure (CHF)
- Sepsis
- Systemic Lupus Erythematosus (SLE)
- Medications