II. Epidemiology

  1. Endemic Hepatitis B
    1. Mediterranean basin
    2. South America
  2. Percutaneous spread via Intravenous Drug Abuse
  3. Transfusion (e.g. Hemophilia)

III. Pathophysiology

  1. Defective 37 nm RNA virus
  2. Requires Hepatitis BVirus for replication
  3. Enhances severity of Hepatitis B infection
  4. Transmission
    1. Coinfection with Hepatitis B
    2. Superinfection of a Hepatitis B Carrier

IV. Differential Diagnosis

V. Labs

  1. Hepatitis D Serology (xHDV)
    1. Higher titers suggest chronic Hepatitis D

VI. Management

VII. Complications

  1. Fulminant Hepatitis
  2. Chronic Hepatitis
  3. Cirrhosis

VIII. Prevention

  1. Hepatitis B Vaccine for Non-Carriers of Hepatitis B

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