II. Pathophysiology

  1. Acute Hepatitis B Infection becomes chronic in 10%
  2. Chronic Hepatitis B (HBsAg present >6 months)
    1. Chronic Hepatitis B Carrier
    2. Chronic Hepatitis B Infection
  3. Hepatitis B Carrier contrasted with chronic infection
    1. Low viral load
    2. Normal Liver Function Tests (ALT or SGPT)

III. Labs

  1. HBsAg positive
  2. HBeAg negative
  3. xHBeAb positive
  4. Liver Function Tests (ALT or SGPT) normal
  5. Low viral load: HBV DNA hybridization negative

IV. Management

  1. Observation: primary care visits every 6-12 months
  2. Follow related lab-work at follow-up visits
    1. Liver Function Tests (ALT or SGPT)
    2. HBsAg
    3. HBeAg
    4. xHBeAb

V. Course

  1. Spontaneous clearance in 1% of carriers per year
  2. Risk of reactivation to Chronic Hepatitis B Infection

VI. Prevention of Transmission

  1. Identify all potential exposures
    1. Children
    2. Household contacts
    3. Sexual contacts
  2. Hepatitis B Serology testing for all exposures
  3. Hepatitis B Vaccine for all exposures not immune

VII. References

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Ontology: Hepatitis B carrier (finding) (C0262505)

Concepts Finding (T033)
SnomedCT 433088006, 235871004
Dutch hepatitis-B-drager, hepatitis B oppervlakteantigeen (HBsAg) drager
French Porteur du virus de l'hépatite B, Porteur de l'antigène de surface de l'hépatite B (AgHBs)
German Hepatitis B Traeger, Hepatitis-B-Oberflaechenantigen-(HBsAg)-Traeger
Italian Portatore di epatite B, Portatore di antigene di superficie del virus dell'epatite B (HBsAg)
Portuguese Portador de antigénio de superfície de hepatite B (HBsAg), Portador de hepatite B
Spanish Portador del antígeno de superficie de la hepatitis B (AgHBs), Portador de hepatitis B, portador de virus de hepatitis B, portador de virus de hepatitis B (hallazgo), portador de hepatitis B (hallazgo), portador de hepatitis B
Japanese B型肝炎キャリアー, B型肝炎表面抗原キャリアー, Bガタカンエンキャリアー, Bガタカンエンヒョウメンコウゲンキャリアー
Czech Nosič povrchového antigenu hepatitidy B (HBsAg), Nosič hepatitidy B
English Hepatitis B surface antigen (HBsAg) carrier, Hepatitis B carrier (finding), b carriers hepatitis, hepatitis b carrier, Carrier of hepatitis B, Carrier of hepatitis B (finding), Hepatitis B carrier
Hungarian Hepatitis B felszíni antigen (HBsAg) hordozó, Hepatitis B hordozó