II. Pathophysiology

  1. Pulmonary or systemic infection of Aspergillus fungi
  2. Occurs in debilitated or Immunocompromised patients

III. Predisposing factors

  1. Chronic illness
  2. Long term use of antibiotics or Corticosteroids
  3. Irradiation

IV. Symptoms

  1. Pulmonary
    1. Dyspnea
    2. Cough
    3. Hemoptysis
  2. Systemic
    1. Skin eruption
    2. Arthralgias
    3. Mental status change

V. Signs

  1. Pulmonary
    1. Fever
    2. Purulent Sputum
  2. Systemic or Disseminated Infection
    1. Skin eruption
    2. Infection of ears, eyes, sinuses

VI. Lab

VII. Radiology: Chest XRay

  1. Pulmonary aspergilloma
    1. Unique crescentic radiolucency
    2. Surrounds a circular shadow

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Related Studies

Ontology: Aspergillosis (C0004030)

Definition (MEDLINEPLUS)

Aspergillosis is a disease caused by a fungus (or mold) called Aspergillus. The fungus is very common in both indoors and outdoors. Most people breathe in the spores of the fungus every day without being affected. But some people get the disease. It usually occurs in people with lung diseases or weakened immune systems.

There are different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA). Symptoms of ABPA include wheezing and coughing. ABPA can affect healthy people but it is most common in people with asthma or cystic fibrosis.

Another kind is invasive aspergillosis, which damages tissues in the body. It usually affects the lungs. Sometimes it can also cause infection in other organs and spread throughout the body. It affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers.

Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, and an examination of tissues for signs of the fungus. Treatment is with antifungal drugs. If you have ABPA, you may also take steroids.

Centers for Disease Control and Prevention

Definition (NCI_NCI-GLOSS) An infectious fungal disease that occurs most often in the skin, ears, nasal sinuses, and lungs of people with suppressed immune systems.
Definition (MSH) Infections with fungi of the genus ASPERGILLUS.
Definition (CSP) disease condition caused by species of Aspergillus and marked by inflammatory granulomatous lesions in the skin, ear, orbit, nasal sinuses, lungs, and sometimes in the bones and meninges.
Concepts Disease or Syndrome (T047)
MSH D001228
ICD9 117.3
ICD10 B44 , B44.9
SnomedCT 266218008, 187492008, 154408001, 187087004, 65553006
English Aspergilloses, Aspergillosis, unspecified, [X]Aspergillosis, unspecified, aspergillosis (diagnosis), aspergillosis, Aspergillosis [Disease/Finding], aspergillose, aspergilloses, Aspergillosis, [X]Aspergillosis, unspecified (disorder), Aspergillosis NOS, Infection due to Aspergillus, Aspergillosis (disorder), Aspergillosis, NOS
Swedish Aspergillos
Czech aspergilóza, Aspergilóza NOS, Aspergilóza
Finnish Aspergilloosi
German Aspergillose, nicht naeher bezeichnet, Aspergillose NNB, Aspergillose
Korean 상세불명의 아스페르길루스증, 아스페르길루스증
Polish Aspergiloza, Kropidlakowica, Zakażenie Aspergillus
Norwegian Aspergillose
Spanish [X]aspergilosis, no especificada (trastorno), [X]aspergilosis, no especificada, Aspergilosis NEOM, aspergilosis (trastorno), aspergilosis, infección por Aspergillus, Aspergilosis
Dutch aspergillose, aspergillose NAO, Aspergillose, niet gespecificeerd, Aspergillose
French Aspergillose SAI, Aspergillose
Hungarian aspergillosis, aspergillosis k.m.n.
Italian Aspergillosi NAS, Aspergillosi
Japanese アスペルギルスショウNOS, アスペルギルスショウ, アスペルギルス症, アスペルギルス症NOS
Portuguese Aspergilose NE, Aspergilose

Ontology: Aspergillus (C0004034)

Definition (NCI) A genus of highly aerobic fungi in the phylum Ascomycota that grow as molds on the surface of a substrate.
Definition (NCI_NCI-GLOSS) Fungi commonly found in soil. Certain types of Aspergillus may cause disease, especially in people who have suppressed immune systems.
Definition (MSH) A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.
Definition (CSP) genus of mitosporic fungi.
Concepts Fungus (T004)
MSH D001230
SnomedCT 2429008
LNC LP19998-1
English Aspergillus, ASPERGILLUS, aspergillus, aspergillus fungus, Aspergillus (organism), Aspergillus, NOS
Swedish Mögelsvamp
Czech Aspergillus
Finnish Aspergillus
Croatian Not Translated[Aspergillus]
Polish Aspergillus, Kropidlaki
Norwegian Aspergillus, Strålemugg
Spanish Aspergillus (organismo), Aspergillus
French Aspergillus
German Aspergillus
Italian Aspergillus
Dutch Aspergillus
Portuguese Aspergillus