II. Lab: Normal
- Range: <25 ug/dl
- Varies by age
III. Physiology
- Long stem (Fc) monomeric Antibody with Molecular weight 180,000 dalton
- Serum Half-Life of 2.5 days
- Reacts to allergans (Type 1 Hypersensitivity) and Parasitic Infections
IV. Causes: Decreased
- Congenital Hypogammaglobulinemia
- Acquired Hypogammaglobulinemia
- Sex-linked Hypogammaglobulinemia
- Ataxia-Telangiectasia
- IgE Deficiency
V. Causes: Increased
- Allergic disorders
- Asthma
- Allergic Rhinitis or Hayfever
- Inhalant allergy
- Atopic Rhinitis or Sinusitis
- Atopic Dermatitis
- Urticaria
- Bronchopulmonary Aspergillus
- Hypersensitivity pneumonitis
- Drug Allergy
- Food Allergy
-
Parasitic Infection
- Ascariasis
- Visceral Larva Migrans
- Toxocara
- Capillariasis
- Echinococcosis
- Hookworm (Necator)
- Amebiasis
- Immunologic disorders
- Hyper-IgE, Recurrent Pyoderma (Job-Buckley Syndrome)
- Thymic dysplasia or deficiency
- Wiskott-Aldrich Syndrome
- Pemphigoid
- Periarteritis Nodosa
- Hypereosinophilic Syndrome
- Neoplasm (i.e. IgE Myeloma)
VI. References
- Bakerman (1984) ABCs of Lab Data, p. 252-3