II. Indications
- Suspected Mononucleosis with negative heterophile tests
- Mononucleosis-Like Syndrome
III. Physiology
- IgM Viral Capsid Antigen (xIgM VCA or EBV IgM)
- Present at onset of symptoms
- Persist for 4-8 weeks after onset
- IgG Viral Capsid Antigen (xIgG VCA or EBV IgG)
- Present early in symptom course
- Persist life long
- Epstein-Barr Virus Nuclear Antibody (xEBNA)
- Suggests past infection
- Not present until 6-8 weeks after symptom onset
IV. Interpretation
- Acute phase antibodies: xEA, xIgM VCA
- Convalescent Antibody: xIgG VCA
- Recovered State: xIgG VCA, xEBNA
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Related Studies
Definition (NCI_CDISC) | A measurement of the Epstein-Barr nuclear antigen in a biological specimen. |
Definition (NCI) | The determination of the amount of Epstein-Barr nuclear antigen present in a sample. |
Concepts | Laboratory Procedure (T059) |
CPT | 86664 |
English | Antibody test; Epstein-Barr (EB) virus, nuclear antigen (EBNA), Antibody; Epstein-Barr (EB) virus, nuclear antigen (EBNA), ANTIBODY EPSTEIN-BARR EB VIRUS NUCLEAR AG EBNA, Epstein-Barr Nuclear Antigen Measurement, Epstein-Barr (EB) virus nuclear antigen (EBNA) antibody titer, EPSTEIN-BARR NUCLEAR ANTIGEN, Epstein-barr nuclear antigen, Epstein-Barr Nuclear Antigen, EBNAG |
Ontology: Antibody test; Epstein-Barr (EB) virus, viral capsid (VCA) (C0373902)
Concepts | Laboratory Procedure (T059) |
CPT | 86665 |
English | Antibody test; Epstein-Barr (EB) virus, viral capsid (VCA), Antibody; Epstein-Barr (EB) virus, viral capsid (VCA), ANTIBODY EPSTEIN-BARR EB VIRUS VIRAL CAPSID VCA, EPSTEIN-BARR CAPSID VCA, Epstein-Barr (EB) virus viral capsid (VCA) antibody titer, Epstein-barr capsid vca |
Ontology: Epstein-Barr virus capsid antibody (C0443705)
Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
SnomedCT | 116869000 |
LNC | LP38068-0, MTHU025100 |
English | Epstein-Barr virus capsid ab, Epstein Barr virus capsid Antibody, Epstein Barr virus capsid Ab, Epstein-Barr virus capsid antibody, Epstein-Barr virus capsid antibody (substance) |
Spanish | anticuerpo anti - cápside del EBV, anticuerpo anti - cápside del VEB, anticuerpo anti - cápside del virus del Epstein Barr (sustancia), anticuerpo anti - cápside del virus del Epstein Barr |
Ontology: Epstein Barr virus capsid Ab.IgG (C0806040)
Concepts | Immunologic Factor (T129) |
LNC | LP38070-6, MTHU024968 |
English | Epstein Barr virus capsid Antibody.immunoglobulin G, Epstein Barr virus capsid Ab.IgG |
Ontology: Epstein Barr virus capsid Ab.IgM (C0806041)
Concepts | Immunologic Factor (T129) |
LNC | LP38071-4, MTHU024970 |
English | Epstein Barr virus capsid Antibody.immunoglobulin M, Epstein Barr virus capsid Ab.IgM |