Immunoglobulin G

Aka: Immunoglobulin G, IgG Immunoglobulin, Gamma Globulin G, IgG

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II. Lab: Normal

  1. Range: 800-1500 mg/dl
  2. Varies by age

III. Physiology

  1. Structure
    1. Accounts for 75% of all Antibody
    2. Subclasses IgG1, IgG2, IgG3, IgG4
    3. Monomer with Molecular weight 160,000 dalton
    4. Serum Half-Life of 23 days
  2. Function
    1. Responsible for long lasting Immunity (secondary immune response) and Type 2 Hypersensitivity
    2. Crosses maternal-fetal membrane
    3. Interacts with complement system
    4. Enhances Phagocytosis by binding Macrophages and PMNs
    5. Enhance cytotoxicity by binding Natural Killer Cells

IV. Causes: Decreased

  1. Hypo-IgG
  2. Protein losing Enteropathy
  3. Nephrotic Syndrome

V. Causes: Increased

  1. Chronic Granulomatous infection
  2. Inflammation
  3. Multiple Myeloma
  4. Liver disease
  5. Infections
  6. Autoimmune Disease

VI. References

  1. Bakerman (1984) ABCs of Lab Data, p. 252-3

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Related Studies

Ontology: Immunoglobulin G (C0020852)

Definition (NCI) An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli.
Definition (CSP) major immunoglobulin in normal human serum, distributed evenly between the intravascular and extravascular pools; it is the major antibody of secondary immune responses and the exclusive antitoxin class.
Definition (MSH) The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) , Pharmacologic Substance (T121)
MSH D007074
SnomedCT 143328001, 165940001, 29246005
LNC LP14672-7, MTHU005225
English 7S Gamma Globulin, Gamma Globulin, 7S, IgG, IgG - Immunoglobulin G, Immunoglobulin G, GAMMA GLOBULIN 07S, Immunoglobulin G [Chemical/Ingredient], immunoglobulin g (IgG), immunoglobulin g, g immunoglobulins, immune globulin,gamma(IgG), Immunoglobulin IgG, Immunoglobulin G (substance), Immunoglobulin IgG (substance), immunoglobulin G, Immunoglobulin IgG, NOS
Swedish Immunglobulin G
Czech imunoglobulin G, IgG
Finnish Immunoglobuliini G
Italian IgG, Gammaglobulina 7S, Immunoglobulina G
Russian IMMUNOGLOBULIN G, GAMMA-GLOBULIN, 7S, IGG, ГАММА-ГЛОБУЛИН, 7S, ИММУНОГЛОБУЛИН G
German GAMMAGLOBULIN 07S, IgG, Immunglobulin G, Gammaglobulin, 7S-
French Gammaglobuline 7S, Globuline gamma 7S, Gamma-globuline 7S, IgG, Immunoglobuline G
Croatian IMUNOGLOBULIN G
Polish Gamma globulina 7S, Immunoglobulina G, IgG
Japanese 7Sガンマグロブリン, 免疫グロブリンG
Spanish inmunoglobulina G, inmunoglobulina G (sustancia), inmunoglobulina IgG, inmunoglobulina IgG (sustancia), IgG, Inmunoglobulina G, gammaglobulina 7S
Portuguese IgG, Imunoglobulina G, gamaglobulina 7s
Derived from the NIH UMLS (Unified Medical Language System)

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