Immunoglobulin G

Aka: Immunoglobulin G, IgG Immunoglobulin, Gamma Globulin G, IgG

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II. Lab: Normal

  1. Range: 800-1500 mg/dl
  2. Varies by age

III. Physiology

  1. Structure
    1. Accounts for 75% of all Antibody
    2. Subclasses IgG1, IgG2, IgG3, IgG4
    3. Monomer with Molecular weight 160,000 dalton
    4. Serum Half-Life of 23 days
  2. Function
    1. Responsible for long lasting Immunity (secondary immune response) and Type 2 Hypersensitivity
    2. Crosses maternal-fetal membrane
    3. Interacts with complement system
    4. Enhances Phagocytosis by binding Macrophages and PMNs
    5. Enhance cytotoxicity by binding Natural Killer Cells

IV. Causes: Decreased

  1. Hypo-IgG
  2. Protein losing Enteropathy
  3. Nephrotic Syndrome

V. Causes: Increased

  1. Chronic Granulomatous infection
  2. Inflammation
  3. Multiple Myeloma
  4. Liver disease
  5. Infections
  6. Autoimmune Disease

VI. References

  1. Bakerman (1984) ABCs of Lab Data, p. 252-3

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