II. Definitions

  1. Sialoadenitis
    1. Inflammation or infection of Salivary Gland or duct
  2. Sialadenosis
    1. Autoimmune Neuropathy induced Salivary Gland localized hypertrophy of the acinar component
    2. Chronic, bilateral, asymptomatic Salivary Gland hypertrophy
    3. Associated with Alcoholism, Diabetes Mellitus, Bulimia Nervosa, Malnutrition
  3. Sialolithiasis
    1. Calculus within Salivary Gland duct and secondary obstruction

III. Causes: Acute versus Chronic Salivary Enlargement

  1. Acute
    1. Unilateral Acute Salivary Swelling
      1. Acute Sialolithiasis (50% of cases)
      2. Bacterial Sialadenitis (fever)
    2. Bilateral Acute Salivary Swelling
      1. Viral Sialadenitis
  2. Chronic
    1. Unilateral Chronic Salivary Swelling
      1. Salivary Gland Tumor
        1. Palpable mass evaluated with CT or Ultrasound, ENT referral and FNA
      2. Salivary Gland Duct Stricture (constant symptoms)
        1. Evaluated with CT, ENT referral and sialography
      3. Chronic Sialolithiasis (recurrent) with Obstructive Sialoadenitis
        1. Stone may be palpable
        2. Evaluate with CT or US and ENT referral
      4. Chronic Bacterial Sialoadenitis (recurrent)
        1. Evaluate with CT, ENT referral and sialography
        2. Treat with oral Antibiotics
      5. Posttreatment Sialadenitis
        1. Follows post-radiation, Radioactive Iodine or Anesthesia
    2. Bilateral Chronic Salivary Swelling in Children
      1. Juvenile Recurrent Parotitis (age 3 to 6 years)
    3. Bilateral Chronic Salivary Swelling in Adults
      1. Systemic Autoimmune Conditions
        1. See Xerostomia
        2. Sjogren Syndrome
        3. Immunoglobulin G4 Related Disease
      2. Chronic infection, inflammation and other febrile causes (eval with labs, u/s, ent referral, FNA)
        1. HIV Infection (associated with bilateral, parotid benign lymphoepithelial cysts)
        2. Fungal Infection
        3. Viral Sialadenitis
        4. Lymphoma
        5. Chronic Granulomatous Disease
          1. Sarcoidosis
          2. Mycobacterial infection (Tuberculosis, Leprosy)
      3. Sialadenosis (asymptomatic, chronic bilateral parotid enlargement)
        1. Eating Disorder (Anorexia, Bulimia Nervosa) or Malnutrition
        2. Alcoholism
        3. Cirrhosis
        4. Chronic Pancreatitis
        5. Endocrine Disorder
          1. Acromegaly
          2. Diabetes Mellitus
          3. Gonadal hypofunction

IV. References

  1. Daniels in Goldman (2000) Cecil Medicine, p. 2245
  2. Kim (2024) Am Fam Physician 109(6): 550-9 [PubMed]

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Related Studies

Ontology: Hypertrophy of salivary gland (C0020569)

Concepts Pathologic Function (T046)
ICD9 527.1
ICD10 K11.1
SnomedCT 196478007, 196480001, 45338009
English SALIVARY GLAND ENLARGEMENT, Salivary gland hypertrophy NOS, Salivary gland hypertrophy, hypertrophy of salivary glands (diagnosis), salivary glands hypertrophy, hypertrophy of salivary glands, salivary gland hypertrophy, Enlargement salivary gland, Salivary gland enlargement NOS, Salivary glnd hyprtrophy, Salivary gland enlargements, Salivary gland hypertrophy NOS (disorder), Hypertrophy of salivary gland, Salivary gland enlargement, Hypertrophy of salivary gland (disorder), Salivary gland hyperplasia, hyperplasia; salivary gland, hypertrophy; salivary gland, salivary gland; hyperplasia, salivary gland; hypertrophy
French Augmentation de taille des glandes salivaires, Augmentation de volume de la glande salivaire, Augmentation de volume d'une glande salivaire SAI, Hypertrophie des glandes salivaires, Hypertrophie de glande salivaire, Hyperplasie d'une glande salivaire, AUGM VOLUME GLANDES SALIVAIRES, Hypertrophies des glandes salivaires
Italian Ingrandimenti delle ghiandole salivari, Ingrandimento delle ghiandole salivari, Ipertrofia delle ghiandole salivari, Ingrandimento di ghiandola salivare, Ipertrofia della ghiandola salivare, Ingrandimento NAS delle ghiandole salivari, Iperplasia della ghiandola salivare
Dutch speekselklierhypertrofie, hypertrofie van speekselklier, speekselkliervergoting NAO, vergroting speekselklier, speekselklierhyperplasie, hyperplasie; speekselklier, hypertrofie; speekselklier, speekselklier; hyperplasie, speekselklier; hypertrofie, Hypertrofie van speekselklier, speekselkliervergoting, speekselkliervergrotingen
German Speicheldruesenvergroesserung NNB, Hypertrophie der Speicheldruese, Speicheldruesenhypertrophie, Hyperplasie der Speicheldruese, SPEICHELDRUESE VERGROESSERT, Vergroesserung der Speicheldruese, Vergroesserungen der Speicheldruesen
Portuguese Aumento de volume de glândula salivar, Aumento de volume das glândulas salivares NE, Hipertrofia das glândulas salivares, Hipertrofia de glândula salivar, Hiperplasia das glândulas salivares, HIPERTROFIA DA GLANDULA SALIVAR, Alargamento das glândulas salivares, Glândulas salivares aumentadas
Spanish Hipertrofia de glándula salival, Aumento de tamaño de la glándula salival NEOM, Hiperplasia de glándula salival, GLANDULA SALIVAL, HIPERTROFIA, hipertrofia de la glándula salival, SAI, hipertrofia de la glándula salival, SAI (trastorno), agrandamiento de la glándula salival, hiperplasia de la glándula salival, hipertrofia de la glándula salival (trastorno), hipertrofia de la glándula salival, Agrandamiento de las glándulas salivales, Aumento de tamaño de la glándula salival
Japanese 唾液腺肥大, 唾液腺の肥大, 唾液腺腫大, 唾液腺腫大NOS, ダエキセンヒダイ, ダエキセンシュダイNOS, 唾液腺過形成, ダエキセンカケイセイ, ダエキセンシュダイ, ダエキセンノヒダイ
Czech Zvětšení slinných žláz, Hypertrofie slinné žlázy, Hyperplazie slinné žlázy, Zvětšení slinné žlázy, Zvětšení slinné žlázy NOS
Korean 침샘의 비대
Hungarian Nyálmirigy megnagyobbodások, Nyálmirigy-hypertrophia, Nyálmirigy hyperplasia, Nyálmirigy megnagyobbodás k.m.n., Nyálmirigy hypertrophia, Nyálmirigy megnagyobbodás, Nyálmirigy-megnagyobbodás

Ontology: Salivary Gland Diseases (C0036093)

Definition (MEDLINEPLUS)

Your salivary glands make saliva - sometimes called spit - and empty it into your mouth through openings called ducts. Saliva makes your food moist, which helps you chew and swallow. It helps you digest your food. It also cleans your mouth and contains antibodies that can kill germs.

Problems with salivary glands can cause the glands to become irritated and swollen. This causes symptoms such as

  • Bad taste in the mouth
  • Difficulty opening your mouth
  • Dry mouth
  • Pain in the face or mouth
  • Swelling of the face or neck

Causes of salivary gland problems include infections, obstruction or cancer. Problems can also be due to other disorders, such as mumps or Sjogren's syndrome.

Definition (NCI) A non-neoplastic or neoplastic (benign or malignant) disorder involving a salivary gland.
Definition (CSP) condition in which there is a deviation from or interruption of the normal structure or function of any of the three pairs of salivary glands, which are the parotid, sublingual, and submandibular glands.
Concepts Disease or Syndrome (T047)
MSH D012466
ICD9 527.9, 527
ICD10 K11.9 , K11
SnomedCT 10890000, 155658007, 155654009, 196526006
English Disease, Salivary Gland, Diseases, Salivary Gland, Gland Disease, Salivary, Gland Diseases, Salivary, Salivary Gland Diseases, Diseases of the salivary glands, Unspecified disease of the salivary glands, salivary disorder, Salivary gland disease NOS, Disease of salivary gland, unspecified, SALIVARY GLAND DIS, salivary gland disorder, Disease of salivary gland, disorder of salivary gland, disorder of salivary gland (diagnosis), Salivary gland disorder NOS, Salivary gland dis NOS, Sialoadenopathy NOS, Diseases of salivary glands, Salivary Gland Diseases [Disease/Finding], disorders gland salivary, disease disorders gland salivary, disorder glands salivary, salivary glands diseases, disorders salivary, diseases gland salivary, disorders glands salivary, salivary gland disease, salivary gland diseases, Salivary Gland Disorders, Salivary gland disease NOS (disorder), Salivary glands--Diseases, Salivary gland disorder, Salivary gland disease, salivary gland; disease, sialoadenopathy, Disease of salivary gland, NOS, Disorder of salivary gland, Disease of salivary gland (disorder), Disorder of salivary gland (disorder), Salivary Gland Disease, Salivary Gland Disorder
Italian Patologia delle ghiandole salivari, Malattie delle ghiandole salivari, Malattia non specificata delle ghiandole salivari, Patologia NAS delle ghiandole salivari, Malattie della ghiandola salivare
Dutch aandoeningen van de speekselklieren, speekselklieraandoeningen NAO, niet-gespecificeerde aandoeningen van de speekselklieren, speekselklier; aandoening, Aandoening van speekselklier, niet gespecificeerd, speekselklieraandoening, Aandoeningen van speekselklieren, Speekselklierziekte, Speekselklierziekten, Ziekte, speekselklier-, Ziekten, speekselklier-
French Affection d'une glande salivaire SAI, Maladie non précisée des glandes salivaires, Affection d'une glande salivaire, Maladies de la glande salivaire, Maladies des glandes salivaires
German Erkrankung der Speicheldruese NNB, unspezifische Erkrankung der Speicheldruesen, Krankheiten der Speicheldruesen, Krankheit der Speicheldruesen, nicht naeher bezeichnet, Erkrankung der Speicheldruese, Speicheldrüsenkrankheiten
Portuguese Alteração das glândulas salivares NE, Doença NE das glândulas salivares, Doenças das glândulas salivares, Alteração das glândulas salivares, Doenças das Glândulas Salivares
Spanish Enfermedades de las glándulas salivales, Enfermedad no especificada de las glándulas salivales, Trastorno de las glándulas salivales NEOM, enfermedad de la glándula salival (trastorno), enfermedad de glándula salival, SAI (trastorno), Salivary gland disease NOS, enfermedad de glándula salival, SAI, Trastorno de las glándulas salivales, trastorno de glándula salival (trastorno), trastorno de glándula salival, enfermedad de la glándula salival, Enfermedades de las Glándulas Salivales
Japanese 唾液腺障害NOS, 唾液腺障害, 詳細不明の唾液腺の疾患, ダエキセンショウガイNOS, ショウサイフメイノダエキセンノシッカン, ダエキセンショウガイ
Swedish Spottkörtelsjukdomar
Finnish Sylkirauhasten sairaudet
Russian SLIUNNYKH ZHELEZ BOLEZNI, СЛЮННЫХ ЖЕЛЕЗ БОЛЕЗНИ
Czech Nemoci slinných žláz, Porucha slinné žlázy NOS, Porucha slinných žláz, Blíže neurčené onemocnění slinných žláz, nemoci slinných žláz, slinné žlázy - nemoci
Korean 상세불명의 침샘 질환, 침샘의 질환
Croatian ŽLIJEZDA SLINOVNICA, BOLESTI
Polish Choroby ślinianek
Hungarian Nyálmirigyek betegségei, Nyálmirigy nem meghatározott betegsége, Nyálmirigy betegség k.m.n., Nyálmirigy betegség
Norwegian Spyttkjertelsykdommer

Ontology: Hypertrophy of parotid gland (C0341047)

Concepts Disease or Syndrome (T047)
SnomedCT 29748005
English PAROTID ENLARGEMENT, Parotid enlargement, Enlargement parotid gland, Parotid gland enlargement of, Parotid hypertrophy, parotid gland enlargement, parotid hypertrophy, parotid enlargement, Hypertrophy of parotid gland, Parotid gland enlargement, Hypertrophy of parotid gland (disorder), hypertrophy; parotid gland
Italian Aumento di volume della ghiandola parotide, Aumento di volume della parotide, Ipertrofia parotidea, Ingrandimento della ghiandola parotide
Dutch parotis vergroting van, parotishypertrofie, vergroting parotis, hypertrofie; parotis, parotisvergroting
French Hypertrophie de la parotide, Tuméfaction de la glande parotide, Tuméfaction parotide, AUGMENTATION VOLUME PAROTIDE, Augmentation de volume de la glande parotide
German Ohrspeicheldruesenvergroesserung, Hypertrophie der Ohrspeicheldruese, OHRSPEICHELDRUESE VERGROESSERT, Parotisvergroesserung
Portuguese Aumento de volume da parótida, Hipertrofia da parótida, AUMENTO DE VOLUME DA PAROTIDA, Aumento de volume da glândula parótida
Spanish Aumento de tamaño de la parótida, Hipertrofia parotídea, PAROTIDA, HIPERTROFIA, agrandamiento de la glándula parótida, hipertrofia de la glándula parótida (trastorno), hipertrofia de la glándula parótida, Aumento de tamaño de la glándula parótida
Japanese 耳下腺腫大, 耳下腺肥大, ジカセンシュダイ, ジカセンヒダイ
Czech Zvětšení příušní žlázy, Hypertrofie příušní žlázy
Hungarian Parotis megnagyobbodás, Megnagyobbodás, parotis, Parotis hypertrophia, Parotis mirigy megnagyobbodás