II. Indications
- Control of minor bleeding (e.g. tongue Laceration) in patients with prolonged INR (e.g. Warfarin)
- Used in combination with gelatins
III. Mechanism
- Topical Hemostatic Agent
- Thrombin facilitates Fibrinogen conversion to fibrin in the formation of clot
IV. Preparations
- Bovine-derived thrombin (Thrombin-JMI)
- Contraindicated in cow allergies
- Human plasma-derived Thrombin (Evithrom)
- Recombinant human thrombin (rhThrombin)
- Topical Thrombin in Gelatin (Floseal)
V. References
- Berry in Schrage (2013) Topical Hemostatic Agents, Medscape Emedicine
- Peralta in Sanfrey (2013) Overview of Topical Hemostatic Agents and tissues adhesives used in the operating room, UpToDate, Wolters-Kluwer
- Achneck (2010) Ann Surg 251(2):217-28 [PubMed]
