Alpha-1 Antitrypsin

Aka: Alpha-1 Antitrypsin, Alpha-1 Proteinase Inhibitor, Aralast, Prolastin, Zemaira, Glassia

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II. Indications

  1. Alpha-1 Antitrypsin Deficiency

III. Contraindications

  1. IgA deficiency AND formed Antibody to IgA

IV. Mechanism

  1. Purified pooled plasma product, replacing deficient Alpha-1 Antitrypsin (Alpha-1 Proteinase Inhibitor)

V. Dosing

  1. Give 60 mg/kg IV weekly

VI. Adverse Effects

  1. Fever
  2. Pooled plasma product
    1. Risk of bood borne pathogens including Creutzfeld-Jakob Disease
    2. Complete Immunizations (including Hepatitis B Vaccine) before use

VII. Safety

  1. Pregnancy Category C
  2. Unknown Safety in Lactation

VIII. Resources

  1. Zemaira Alpha-1 Proteinase Inhibitor Plasma (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c3354b5-a1d8-4f98-ad55-2eafe4265c4e
  2. Prolastin-C Alpha-1 Proteinase Inhibitor Plasma (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=91edab72-c889-470e-8315-1798b5548dca
  3. Aralast NP Alpha-1 Proteinase Inhibitor Plasma (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9a5b46e-04da-41bd-bb5f-c4936b664fef

IX. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 90
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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