II. Indications
- Infectious cough (may speed recovery)
- Chronic Bronchitis (clear airway mucus)
- Acute Sinusitis (assists with sinus drainage)
III. Medications: Guaifenesin
- Short acting agents (e.g. Robitussin)
- Ages 2 to 5 years old: 2.5 ml PO q4h
- Ages 6 to 12 years old: 5 ml PO q4h
- Adults: 10 ml PO q4h
- Long acting agents
- Mucinex (Over-the-counter)
- Humabid LA with new, unproven formulation
- Contains guiacolsulfonate (old expectorant)
- Discontinued agents
- Prior Humibid LA, Liquibid, Guaifenex LA
- Effect
- The only effective expectorant medication per FDA
- Paradoxically also reduces cough in URI
- Due to altered cough Receptor Sensitivity in URI
- Dicpinigaitis (2003) Chest 124:2178-81 [PubMed]
IV. Medications: Other Expectorant Preparations (use with caution)
- Nebulized Hypertonic Saline
-
Terbutaline (Brethine)
- Beta Adrenergic Agonist (Tachycardia risk)
- Dose (age >12): 2.5 to 5 mg PO q6 hours while awake
- Amiloride (Midamor)
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Related Studies
| guaifenesin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| GUAIFENESIN 100 MG/5 ML LIQUID | Generic OTC | $0.01 per ml |
| GUAIFENESIN 200 MG TABLET | Generic OTC | $0.03 each |
| GUAIFENESIN 400 MG TABLET | Generic OTC | $0.06 each |
| GUAIFENESIN DM SYRUP | Generic OTC | $0.02 per ml |
| GUAIFENESIN ER 600 MG TABLET | Generic OTC | $0.33 each |
| GUAIFENESIN-DM 400-20 MG TAB | Generic OTC | $0.08 each |
| GUAIFENESIN-PSE ER 1200-120 MG | Generic OTC | $0.56 each |
| GUAIFENESIN-PSE ER 600-60 MG | Generic OTC | $0.38 each |