Milk Thistle

Aka: Milk Thistle, Silybum marianum, Silymarin

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II. Uses

  1. Liver disease (Cirrhosis, Hepatitis)
    1. Mixed results in clinical trials
  2. Amanita phalloides Poisoning
    1. Insufficient evidence to date

III. Investigational

  1. Cytoprotection (environmental hazards, Chemotherapy)
  2. Anticarcinogen

IV. Adverse Effects

  1. Mild gastrointestinal upset

V. Drug Interactions

  1. No significant interactions
  2. Possible CYP2C9 Inhibitor depending on Genotype

VI. Dosing

  1. Optimal dosing not yet established

VII. References

  1. Rainone (2005) Am Fam Physician 72:1285-8 [PubMed]

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