II. Pathophysiology
- Glucosamine is endogenous amino sugar, a precursor of glycosaminoglycans
- Glycosaminoglycans are present in joint structures such as Synovial Fluid
- Effects
- Stimulates chondrocyte metabolism
- May have anti-inflammatory effects at higher dose
III. Source
- Marine exoskeleton or
- Synthetically derived
IV. Efficacy
- Appears more effective than Placebo at relieving Osteoarthritis-related Joint Pain
- Effect requires at least one month of therapy
- Less Knee Joint space narrowing with Glucosamine over Placebo in 3 years
V. Dosing
- Glucosamine 500 mg orally three times daily
VI. Adverse Effects
- Gastrointestinal upset
-
Hemoglobin A1C and Serum Glucose are NOT impacted (contrary to initial reports)
- Scroggie (2003) Arch Intern Med 163:1587-90
- Glucosamine is safe in shellfish allergy (despite marine exoskeleton source)
VII. Drug Interactions
-
Warfarin (Coumadin)
- Warfarin's Anticoagulation effect is increased
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| Definition (CSP) | amino sugar derivative of glucose, substituted at the 2 position, occurring in glycosaminoglycans and a variety of complex polysaccharides such as blood group substances. |
| Concepts | Carbohydrate (T118) , Pharmacologic Substance (T121) |
| MSH | D005944 |
| SnomedCT | 70237008, 408111007 |
| English | Glucosamine, 2-Amino-2-Deoxyglucose, glucosamine, D-Glucose, 2-amino-2-deoxy-, glucosamine (medication), GLUCOSAMINE, Glucosamine [Chemical/Ingredient], glucosamines, glycosamine, glucosamine products, 2 Amino 2 Deoxyglucose, Glycosamine, Glucosamine (substance), Glucosamine (product), Glucosamine product |
| Swedish | Glukosamin |
| Czech | glukosamin |
| Finnish | Glukosamiini |
| Russian | GLIUKOZAMIN, ГЛЮКОЗАМИН |
| Japanese | キトサミン, グルコサミン |
| Polish | Glukozamina |
| Norwegian | Glukosamin |
| Spanish | glicosamina, glucosamina (sustancia), glucosamina, glucosamina (producto), Glucosamina |
| French | Chitosamine, Glucosamine, Glycosamine |
| German | Glucosamin, Glukosamin |
| Italian | Glucosamina |
| Portuguese | Glucosamina |
