II. Indications
III. Physiology
- Endogenous compound synthesized in liver from Methionine
- Increases chondrocytes and decreases their Cytokine-induced damage
- Increases cartilage thickness
IV. Efficacy
- Symptom improvement does not occur for weeks after starting treatment
- Comparable to NSAIDs for Osteoarthritis pain
- Although Celebrex was more effective in the first month, no difference at 3 months
- References
V. Adverse Effects
- May be better tolerated than NSAIDs
- Serotonergic effects
- Anxiety
- Headache
- Mania
- Risk of Serotonin Syndrome
VI. Dosing
- SAMe 200 mg orally three times daily
VII. Disadvantages
- Very expensive
- Short and unpredictable shelf life
- Butanedisulfonate salt formulation appears to be most stable of available preparations
VIII. References
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Related Studies
| Definition (NCI) | Equal, or closely similar or comparable, in kind or quality or quantity or degree. |
| Concepts | Qualitative Concept (T080) |
| SnomedCT | 262126009 |
| LNC | LA11009-0 |
| English | Same, Idem, same, SAME, Same (qualifier value) |
| Spanish | mismo (calificador), mismo |
Ontology: S-Adenosylmethionine Pill (C3210896)
| Concepts | Clinical Drug (T200) |
| English | S-Adenosylmethionine Pill |
