II. Mechanism

  1. Yams are among 600 species of Dioscorea family
  2. Yams have Estrogenic Activity in animals
  3. Diosgenin is derived from yams
    1. Natural Progesterone source
    2. Highest concentration of Disogenin in Mexican Yam
    3. Diosgenin not converted to Progesterone in humans
    4. Diosgenin converted in labs to Progesterone

III. Current Uses

  1. Premenstrual Syndrome
  2. Menopausal symptoms
  3. Osteoporosis

IV. Dosing: Natural Progesterone cream (not Yam extract)

  1. Preparation: 400 mg per ounce
  2. Apply 1/4 to 1/2 teaspoon to vagina per day

V. Efficacy

  1. Yams
    1. Yam extract has no Progesterone activity in humans
    2. Yam Estrogen levels are not high enough for benefit
  2. Natural Progesterone derived from Diosgenin
    1. May relieve some post-menopausal symptoms
    2. Minimal or no benefit in Osteoporosis

VI. Adverse Effects

  1. Yams are an Unopposed Estrogen source
    1. Risk of Endometrial Cancer
    2. May require Endometrial Biopsy

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Related Studies

Ontology: Wild yam extract (C0772357)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Wild Yam Extract, WILD YAM, Wild Yam, wild yam (medication), wild yams, Wild yam extract, wild yam

Ontology: Genus Dioscorea (C0936043)

Definition (MSH) A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.
Concepts Plant (T002)
MSH D027742
SnomedCT 50918006
Swedish Dioscorea
English Dioscorea L., Dioscoreas, dioscorea, yam, yam plant, yams, Dioscorea, Yam, Dioscorea (organism), Genus Dioscorea, Dioscorea, NOS, Tamus, Nanarepenta, Borderea
Czech Dioscorea
Finnish Dioscorea
French Dioscorée, Dioscorea
Polish Pochrzyn, Ignam, Jams
Norwegian Dioscorea
Portuguese Cará-da-Guiné, Cará-de-Angola, Cará-de-Folha-Colorida, Cará-Inhame, Cará-de-Pedra, Cará-de-Pele-Branca, Inhame, Cará-de-Sapateiro, Cará-do-Ar, Dioscorea batatas, Caratinga, Cará-de-Folha-Miúda, Cará-de-São-Tomé, Inhame-Comum, Cará-Doce, Cará-de-Árvore, Cará-do-Pará, Dioscorea batata, Inhame-da-China, Dioscorea
Spanish Dioscorea (organismo), Dioscorea
German Dioscorea
Italian Dioscorea
Dutch Dioscorea