Natural Progesterone

Aka: Natural Progesterone, Dioscorea, Yam extract, Wild Yam

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II. Mechanism

  1. Yams are among 600 species of Dioscorea family
  2. Yams have Estrogenic Activity in animals
  3. Diosgenin is derived from yams
    1. Natural Progesterone source
    2. Highest concentration of Disogenin in Mexican Yam
    3. Diosgenin not converted to Progesterone in humans
    4. Diosgenin converted in labs to Progesterone

III. Current Uses

  1. Premenstrual Syndrome
  2. Menopausal symptoms
  3. Osteoporosis

IV. Dosing: Natural Progesterone cream (not Yam extract)

  1. Preparation: 400 mg per ounce
  2. Apply 1/4 to 1/2 teaspoon to vagina per day

V. Efficacy

  1. Yams
    1. Yam extract has no Progesterone activity in humans
    2. Yam Estrogen levels are not high enough for benefit
  2. Natural Progesterone derived from Diosgenin
    1. May relieve some post-menopausal symptoms
    2. Minimal or no benefit in Osteoporosis

VI. Adverse Effects

  1. Yams are an Unopposed Estrogen source
    1. Risk of Endometrial Cancer
    2. May require Endometrial Biopsy

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