II. Indications

  1. Uses with good supporting evidence
    1. Morning Sickness or Hyperemesis Gravidarum
    2. Postoperative Nausea or Vomiting
  2. Uses with variable evidence to support
    1. Osteoarthritis
    2. Chemotherapy-Induced Nausea
  3. Conditions in which Ginger is ineffective (avoid)
    1. Motion Sickness

III. Dosing

  1. General range: 250 to 1000 mg orally daily to four times daily
  2. Pregnancy-induced Nausea: 250 mg orally four times daily

IV. Adverse Effects

  1. Mild gastrointestinal upset (e.g. Reflux, Eructation or Diarrhea)
  2. Antiplatelet effects
    1. May increase bleeding risk (avoid within 2 weeks of surgery)
  3. Hypoglycemia

V. Safety

  1. Pregnancy
    1. Mixed safety results
      1. If used in pregnancy, then use with caution and limit to first trimester
      2. Late pregnancy use is associated with bleeding, prematurity and decreased Head Circumference in some studies
        1. Other studies have shown no increased risk of preterm birth or low birth weight
    2. Effects
      1. Ginger affects Testosterone binding
      2. Ginger affects Thromboxane synthetase activity
      3. Animal studies showed increased Embryo loss
    3. References
      1. Larimore (2000) Prim Care 27(1): 35-53 [PubMed]

VI. Drug Interactions

  1. No major P450 or P-Glycoprotein interactions
  2. Warfarin (Coumadin)
    1. Possible interaction

VII. Efficacy: Ginger appears effective in Morning Sickness

  1. Effective, safe and well tolerated
    1. Smith (2004) Obstet Gynecol 103:639-45 [PubMed]
  2. Dose of 250 mg four times daily showed benefit in 70% of cases
    1. Vutyavanich (2001) Obstet Gynecol 97:577-82 [PubMed]

VIII. Cost

  1. Inexpensive (<$20 per month)

IX. References

Images: Related links to external sites (from Bing)

Related Studies