Chromium Picolinate

Aka: Chromium Picolinate

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II. Background

  1. Chromium Picolinate is listed for historical purposes only
  2. Chromium Picolinate has been replaced since the 1960s by more potent hypoglycemic agents

III. Indications

  1. Type II Diabetes Mellitus
  2. Weight Loss
    1. Commonly found in weight loss drugs

IV. Mechanism

  1. Chromium Picolinate is a salt of Chromium and picolinic acid
    1. Chromium is a trace metallic element that is an InsulinCofactor
    2. Picolinic acid is a natural derivative of Tryptophan
  2. Chromium Picolinate effects
    1. Increases Lean Body Mass
    2. Decreases percentage body fat
    3. Increases basal metabolic rate

V. Dosing: Diabetes Mellitus

  1. Chromium Picolinate 200 to 500 mcg/day

VI. Efficacy

  1. Advantages
    1. Inexpensive: 4 cents per day (however, so are the more effective Sulfonylureas and Metformin)
    2. Improves Insulin sensitivity
    3. Improves Lipid Metabolism
  2. Disadvantages
    1. Toxicity
    2. Weak agent compared with newer hypoglycemics

VII. Adverse Effects

  1. Acute Kidney Injury
  2. Rhabdomyolysis

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