II. Background
- Chromium Picolinate is listed for historical purposes only
- Chromium Picolinate has been replaced since the 1960s by more potent hypoglycemic agents
III. Indications
- Type II Diabetes Mellitus
- Weight Loss
- Commonly found in weight loss drugs
IV. Mechanism
- Chromium Picolinate is a salt of Chromium and picolinic acid
- Chromium is a trace metallic element that is an InsulinCofactor
- Picolinic acid is a natural derivative of Tryptophan
- Chromium Picolinate effects
- Increases Lean Body Mass
- Decreases percentage body fat
- Increases basal metabolic rate
V. Dosing: Diabetes Mellitus
- Chromium Picolinate 200 to 500 mcg/day
VI. Efficacy
- Advantages
- Inexpensive: 4 cents per day (however, so are the more effective Sulfonylureas and Metformin)
- Improves Insulin sensitivity
- Improves Lipid Metabolism
- Disadvantages
- Toxicity
- Weak agent compared with newer hypoglycemics
VII. Adverse Effects
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Related Studies
| Definition (NCI) | Chromium Piccolinate is a salt of the trace metallic element chromium (Cr), essential in glucose metabolism. Found in vitamins and mineral supplements, Chromium may be necessary for utilization of dietary sugars and carbohydrates by optimizing the effects of insulin. Animal studies suggest that chromium picolinate may be carcinogenic, it enters cells directly and can causes mutations. (NCI04) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C030614 |
| SnomedCT | 442428005 |
| English | CHROMIUM PICOLINATE, mineral supplements chromium picolinate, chromium picolinate (medication), Chromium Picolinate, Chromium picolinate (substance), Chromium picolinate, chromium picolinate |
| Spanish | picolinato de cromo (sustancia), picolinato de cromo |
