Blue Cohosh

Aka: Blue Cohosh, Caulophyllum thalictroides

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II. Current use

  1. Oxytocin-like agent used in Labor Augmentation

III. Contraindications

  1. Hypertension
  2. Underlying Cardiovascular disease

IV. Mechanism

  1. Perennial plant growing in North America
    1. Member of Berberidaceae family
  2. Active ingredients
    1. Glycoside: Caulosaponin
    2. Alkaloid: Methylcysteine (Nicotine-like compound)
      1. Increases Blood Pressure
      2. Stimulates uterine contractions
      3. Stimulates gastrointestinal motility
      4. Stimulates coronary Vasoconstriction

V. Efficacy

  1. No studies supporting efficacy or safety

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