Collagen Supplement

Aka: Collagen Supplement, Oral Collagen Peptide, Hydrolyzed Collagen, Collagen Hydrolysate

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II. Background

  1. Highly touted fad product in 2022 marketed for many unsupported claims
  2. Costly ($100/month in 2022)
  3. Dosing is not standardized (study doses ranged from 370 mg to 12 grams/day)
  4. Evidence supports some uses (see indications below)
    1. Limited trial for 3 to 6 months may be reasonable for evidence-based indications
    2. Stop if no effect seen

III. Indications (Evidence Supported)

  1. Knee Osteoarthritis Pain
    1. Oral Collagen Peptides 10 g/day
    2. Zdzieblik (2021) Nutrients 13(2): 523 [PubMed]
  2. Skin Hydration and Elasticity
    1. Oral Collagen Peptides 4 to 10 g/day
    2. May offer no visible reduction in Wrinkles
    3. Bolke (2019) Nutrients 11(10): 2494 [PubMed]

IV. Preparations: Collagen Types

  1. Background
    1. Supplements are composed of small Collagen fragments
  2. Type 1 Collagen
    1. Sources: Fish, cow
    2. Found in bone, tendons, ligaments and skin
  3. Type 2 Collagen
    1. Sources: Chicken cartilage
    2. Found in cartilage
  4. Type 3 Collagen
    1. Sources: cow
    2. Found in skin, blood vesels and various organs

V. Adverse Effects

  1. Gastrointestinal
  2. Skin rash (rare)

VI. Drug Interactions

  1. No significant known Drug Interactions

VII. Resources

  1. Mayo Clinic Q and A: Collagen and Biotin supplements
    1. https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-collagen-and-biotin-supplements/

VIII. References

  1. (2022) Presc Lett 29(7): 42
  2. (2024) Presc Lett 31(6): 36

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