II. Precautions
- Green Tea is safe, but NOT Green Tea extract
- Avoid Green Tea extract (risk of liver toxicity)
III. Indications: Topical
- Genital and Perinanal Warts (Sinecatechins or Veregen 15% is FDA approved)
IV. Indications: Oral
-
General
- Conflicting data on benefits
- Various forms (capsules, Green Tea beverages)
- Potential benefits (requires additional study)
- Colorectal Cancer risk reduction
- Breast Cancer Risk Reduction
- Weight Reduction
- Cholesterol reduction
- Cardiovascular disease risk reduction
V. Contraindications
- Pregnancy (due to theororetical anti-Folate activity)
VI. Dosing: Topical (15% Sinecatechins)
- Apply 0.5 cm per wart three times daily for 16 weeks
VII. Dosing: Oral
- Typical dose: 3 cups Green Tea per day (~320 mg Polyphenols)
- Most studies used between 3-5 cups/day of Green Tea
VIII. Adverse Effects: Topical
- Contact reaction (allergic or irritant)
IX. Adverse Effects: Oral
- Gastrointestinal upset
- Hepatotoxicity (case reports)
X. Drug Interactions: General
-
Warfarin
- Possible warfarin Antagonist at high dose (due to Vitamin K)
XI. Drug Interactions: OATP Inhibitor (Organic anion-transporting polypeptide inhibitor)
- Background
- Orange juice, apple juice and Grapefruit juice also inhibit the OATP transporter
- Catechins in Green Tea also inhibits the OATP transporter
- Green Tea 12 oz twice daily may have a Clinically Significant effect
- Medications affected
- References
- (2014) Presc lett 21(3)