Drug-Drug Interactions in the Elderly

Aka: Drug-Drug Interactions in the Elderly

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II. Adverse Effect: Increased Drug effect (common)

  1. Azathioprine (Imuran, Bone Marrow suppression risk)
    1. Allopurinol
  2. Benzodiazepines and other Sedative Hypnotics (Sedation risk)
    1. Alcohol
  3. Digoxin (Digoxin Toxicity risk)
    1. Diuretics
    2. Quinidine
  4. Methotrexate (Bone Marrow suppression risk)
    1. Aspirin
    2. Sulfisoxazole
  5. Phenytoin (Ataxia and sedation risk)
    1. Chloramphenicol
    2. Isoniazid
    3. Phenylbutazone
  6. Propranolol (Bradycardia risk)
    1. Cimetidine (Tagamet)
  7. Sulfonylureas (Hypoglycemia risk)
    1. Chloramphenicol
    2. Phenylbutazone
    3. Warfarin
  8. Warfarin (Bleeding risk)
    1. Aspirin
    2. Metronidazole
    3. Phenylbutazone

III. Adverse Effect: Decreased Drug effect (common)

  1. Metformin
    1. Risperidone
  2. Pioglitazone (Actos)
    1. Olanzapine (Zyprexa)
  3. Prednisone
    1. Barbiturates
  4. Quinidine
    1. Barbiturates
    2. Rifampin
  5. Tetracycline
    1. Antacids
  6. Warfarin
    1. Barbiturates
    2. Rifampin

IV. References

  1. Bressler (2003) Mayo Clin Proc 78:1564-77 [PubMed]

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