Carboxyhemoglobin

Aka: Carboxyhemoglobin

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II. Pharmacokinetics: Carbon MonoxideHalf-Life

  1. Room air
    1. Carbon MonoxideHalf-Life: 320 min
  2. Non-rebreather at 100% FIO2
    1. Carbon MonoxideHalf-Life: 80 min
  3. Hyperbaric oxygen at 3 Atmospheres
    1. Carbon MonoxideHalf-Life: 23 min

III. Causes: Increased

  1. See Carbon Monoxide for sources
  2. Carbon Monoxide Poisoning
  3. Smoke Inhalation

IV. Findings: Carboxyhemoglobin level

  1. Carboxyhemoglobin: 10%
    1. Frontal Headache
  2. Carboxyhemoglobin: 20%
    1. Throbbing Headache
    2. Dyspnea on exertion
  3. Carboxyhemoglobin: 30%
    1. Impaired judgment
    2. Nausea or Vomiting
    3. Dizziness
    4. Visual disturbance
    5. Fatigue
  4. Carboxyhemoglobin: 40%
    1. Confusion
    2. Syncope
  5. Carboxyhemoglobin: 50%
    1. Coma
    2. Seizures
  6. Carboxyhemoglobin: 60%
    1. Hypotension
    2. Respiratory Failure
  7. Carboxyhemoglobin: 70%
    1. Death

V. References

  1. Rothrock (2009) Adult Emergency Pocketbook, Tarascon, p. 170

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