II. Indications
- East African Trypanosomiasis (T. rhodesiense)
- Stage 2 AND (Age <6 years OR body weight >20kg)
- Fexindazole is preferred in other cases
III. Contraindications
- G6PD Deficiency
- Pregnancy
IV. Mechanism
- Arsenical agent used in Trypanosomias
V. Dosing
- Melarsoprol 2.2 mg/kg/day IV for 10 days
- Consider Corticosteroid pretreatment to prevent encephalopathy
- Consider pretreatment with Suramin to treat blood stages before Melarsoprol
VI. Pharmacokinetics
- Penetrates the blood brain barrier and CNS
VII. Adverse Effects
- Encephalopathy (5-10% of patients)
- High mortality (>50%)
- Consider Corticosteroid pretreatment to prevent encephalopathy
- Jarisch-Herxheimer Reaction
- Hemolysis in G6PD Deficiency
- Blood Pressure elevation
- Gastrointestinal symptoms (Nausea, Vomiting, Abdominal Pain)
- Peripheral Neuropathy
- Pruritus
- Phlebitis
VIII. Safety
IX. Resources
X. References
- Gladwin, Trattler and Mahan (2014) Clinical Microbiology, Medmaster, Fl, p. 349
- Freedman (2025) Sanford Guide, accessed 7/11/2025 on IOS
- Ortiz-MartÃnez (2023) Curr Trop Med Rep 10(4):222-34 +PMID: 38939748 [PubMed]