II. Definitions

  1. Transplant
    1. Biologic object transferred from one anatomic site to another

III. Types

  1. Autograft
    1. Transplantation of tissue within the same patient (e.g. skin graft)
  2. Synergeneic Graft (Syngraft, Isograft)
    1. Transplantation of tissue between identical twins
  3. Allogeneic Graft (Allograft)
    1. Transplant between non-genetically identical persons (e.g. Blood Transfusion)
  4. Xenogeneic Graft (Xenograft)
    1. Transplant between species (e.g. bovine Heart Valve transplant in humans)

IV. Epidemiology

  1. Transplantant Incidence: Approaches 39,719 per year with over 7397 live donor transplants (2019, U.S.)
    1. Kidney Transplant (23,401)
    2. Liver Transplant (8,896)
    3. Heart Transplant (3,552)
    4. Lung Transplant (2,714)
    5. Kidney-Pancreas Transplant (872)
    6. Pancreas Transplant (143)
    7. Intestine Transplant (81)
    8. Heart-Lung Transplant (45)
  2. References
    1. United Network for Organ Sharing (UNOS, accessed 11/6/2020)
      1. https://unos.org/data/transplant-trends/

V. Physiology

  1. Graft success depends on Immune System acceptance of the transplanted tissue
    1. Autografts (from self) and Syngrafts (between twins) are accepted as self
    2. Blood Transfusions are matched between donor and recipient by ABO, Rh (and other Antigens)
  2. Allogenic grafts are rejected without HLA matching and suppressing immune response
    1. Major Histocompatibility Complex or MHC (Human Leukocyte Antigen or HLA Complex) matching
    2. Immunosuppressive Medications (e.g. Corticosteroids, cyclosporin, Tacrolimus, Sirolimus)

VI. Types

  1. Cardiopulmonary
    1. Lung Transplant
    2. Heart Transplant
  2. Eye
    1. Cornea Transplant
  3. Gastrointestinal
    1. Liver Transplant
    2. Kidney Transplant
    3. Pancreas Transplant
    4. Intestine Transplant
  4. Hematologic
    1. Blood Transfusion
    2. Bone Marrow Transplant
  5. Skin (Autografts)
    1. Hair Transplant
    2. Skin Transplant

VII. References

  1. Mahmoudi (2014) Immunology Made Ridiculously Simple, MedMaster, Miami

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Transplantation (C0040732)

Definition (SCTSPA) Movilización de tejido corporal o células desde el sitio donante al sitio receptor
Definition (SNOMEDCT_US) To move body tissue or cells from donor site to recipient site
Definition (MSH) Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Definition (CSP) transferring cells, tissues or organs within an individual, between individuals of the same species, or between individuals of different species.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D014180
SnomedCT 360011002, 77465005, 263903005, 129406001
LNC LA18638-9
English Transplantations, transplantation, TRANSPL, TX - Transplant, procedures transplantation, transplanted, transplanting, transplant procedure, transplantations, procedures transplant, transplant, transplantation procedure, Transplant, Transplant procedure, Tx - Transplant, Transplant (qualifier value), Transplantation (procedure), Transplantation - action (qualifier value), Transplantation - action, Transplantation, Transplantation, NOS
Swedish Transplantation
Japanese イショク, 移植, 移植術
Czech transplantace, Transplantace
Finnish Transplantaatio
Russian TRANSPLANTATSIIA, ТРАНСПЛАНТАЦИЯ
Spanish trasplante - acción, trasplante (acción), Trasplante (Técnica), Injerto (Técnica), Trasplantación, trasplante, trasplante (calificador), trasplante (procedimiento), trasplante - acción (calificador), Trasplante
French Greffe (procédure), Greffe, Greffon, Transplantation
Croatian TRANSPLANTACIJA
Polish Przeszczepianie, Transplantacja
Hungarian Transzplantáció
Norwegian Transplantasjon
Portuguese Transplantação, Enxertia, Transplante (Técnica), Transplante
Dutch transplantaat, Transplantatie
German Transplantat, Transplantation, Verpflanzung
Italian Trapianto

Ontology: Transplantation, Homologous (C0040739)

Definition (SCTSPA) Trasplante en el cual los sitios receptor y donante pertenecen a distintos individuos de la misma especie
Definition (SNOMEDCT_US) A transplantation where the donor and recipient spots are from antigenically distinct individuals of the same species
Definition (NCI_NCI-GLOSS) The transplant of an organ, tissue, or cells from one individual to another individual of the same species who is not an identical twin.
Definition (NCI) Grafting or transplanting cells, tissues, or organs between genetically non-identical individuals.
Definition (CSP) transplantation between individuals of the same species.
Definition (MSH) Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D014184
ICD10 90670-00
SnomedCT 50223000
English Allogeneic Transplantation, Allograft, Homologous Transplantation, Transplantation, Allogeneic, Transplantation, Homologous, homologous transplantation, allogeneic transplantation, TRANSPL HOMOL, ALLOGENEIC TRANSPL, HOMOL TRANSPL, TRANSPL ALLOGENEIC, homograft, allografting, allografts, homografting, homografts, Allografting, Homografting, allograft, Homotransplantation, Allogeneic transplantation, Allogeneic transplantation (procedure)
Swedish Allotransplantation
Czech transplantace alogenní, aloštěp, alogenní transplantace, homoštěp, transplantace homologní, homologní transplantace
Finnish Homologinen transplantaatio
Italian Omoinnesto, Trapianto allogenico, Trapianto omologo
Russian ALLOTRANSPLANTATSIIA, TRANSPLANTATSIIA GOMOLOGICHESKAIA, TRANSPLANTATSIIA ALLOGENNAIA, GOMOLOGICHESKAIA TRANSPLANTATSIIA, АЛЛОТРАНСПЛАНТАЦИЯ, ГОМОЛОГИЧЕСКАЯ ТРАНСПЛАНТАЦИЯ, ТРАНСПЛАНТАЦИЯ АЛЛОГЕННАЯ, ТРАНСПЛАНТАЦИЯ ГОМОЛОГИЧЕСКАЯ
Japanese 同種異系移殖片, 同種間移植, 移植-同種, 移植-同種間, 同種移植片, 同種移植, アログラフト
French Transplantation homologue, Transplantation allogénique, Homoplastie, Homotransplantation
Croatian TRANSPLANTACIJA, HOMOLOGNA
Polish Przeszczep homogenny, Przeszczepianie homologiczne, Przeszczep allogeniczny, Alloprzeszczep
Norwegian Transplantasjon, allogen, Homolog transplantasjon, Transplantasjon, homolog, Allogen transplantasjon
Spanish Trasplantación Homóloga, Trasplantación Alogénica, alotrasplante (procedimiento), alotrasplante, homotrasplante, Trasplante Alogénico, Trasplante Homólogo
Portuguese Transplantação Homóloga, Transplantação Alogênica, Enxerto Alogênico, Transplante Alogênico, Transplante Homólogo
German Homograft, Homotransplantat, Transplantation, allogene, Transplantation, homologe
Dutch Allotransplantaat, Homologe transplantatie, Transplantatie, allogene, Transplantatie, homologe

Ontology: Xenograft procedure (C0520484)

Definition (MSH) Transplantation between animals of different species.
Definition (CSP) procedures in which live cells, tissues, or organs derived from one species are transplanted, implanted, or infused into another species; includes those procedures from an animal into a human or from one animal into another; also includes procedures in which human body fluids, cells, tissues, or organs are removed from the body, come into contact with live animal cells, tissues, or organs, and are then placed back into a human patient; this definition is based upon the DHHS definition; where appropriate, index donor and recipient species.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D014183
ICD10 90671-00
SnomedCT 53959004
English Heterologous Transplantation, Transplantation, Heterologous, Xenograft, Xenotransplantation, Xenograft procedure, xenograft, HETEROL TRANSPL, XENOTRANSPL, TRANSPL HETEROL, xenotransplantation, xenografting, xenografts, Transplantation, Xenograft, Heterograft Transplantation, Heterografting, Xenografting, Xenograft Transplantation, Transplantation, Heterograft, Xenogeneic transplantation, Animal-human transplantation, Heterologous transplantation, Xenogeneic transplantation (procedure), heterologous transplantation
Swedish Xenotransplantation
Czech transplantace heterologní, xenotransplantát
Finnish Heterologinen transplantaatio
Italian Xenoinnesto, Eteroinnesto, Xenotrapianto, Trapianto eterologo
Russian TRANSPLANTATSIIA GETEROLOGICHESKAIA, KSENOTRANSPLANTATSIIA, GETEROLOGICHESKAIA TRANSPLANTATSIIA, KSENOTRANSPLANTAT, GETEROTRANSPLANTAT, ГЕТЕРОЛОГИЧЕСКАЯ ТРАНСПЛАНТАЦИЯ, ГЕТЕРОТРАНСПЛАНТАТ, КСЕНОТРАНСПЛАНТАТ, КСЕНОТРАНСПЛАНТАЦИЯ, ТРАНСПЛАНТАЦИЯ ГЕТЕРОЛОГИЧЕСКАЯ
Japanese 異種移植, ヘテロ移植, 異体移植, 異種移植片, 移植-異種, 異種間移植
French Xénogreffe, Transplantation hétérologue, Hétérogreffe, Greffe hétérologue, Greffe hétéroplastique, Greffe xénoplastique, Héteroplastie, Hétérotransplantation
Croatian TRANSPLANTACIJA, HETEROLOGNA
Polish Przeszczep ksenogenny, Przeszczepianie ksenogeniczne, Przeszczepianie heterologiczne, Ksenoprzeszczep
Norwegian Xenotransplantasjon, Transplantasjon, xenolog, Heterotransplantasjon
Spanish Trasplantación Heteróloga, trasplante animal - humano, trasplante heterólogo, xenoinjerto, xenotrasplante (procedimiento), xenotrasplante, Trasplante Heterólogo, Xenotrasplantación
Portuguese Transplantação Heteróloga, Transplante Heterólogo, Xenotransplante
German Heterotransplantat, Transplantation, heterologe, Transplantation, xenogene, Xenogene Transplantation, Xenotransplantat, Interspeziestransplantation
Dutch Heterologe transplantatie, Transplantatie, heterologe, Xenotransplantaat, Xenotransplantatie

Ontology: Autograft Material (C0559189)

Definition (MSH) Transplant comprised of an individual's own tissue, transferred from one part of the body to another.
Definition (NCI) A graft transferred from one location to another within the same individual.
Concepts Biomedical or Dental Material (T122)
MSH D064592
SnomedCT 15879007, 123146007
English Autochtonous graft, Autochthonous graft, Autograft Material, autograft, autografting, autologous grafting, autogenous graft, autochtonous graft, Autologous Transplants, Transplant, Autologous, Autotransplants, Autotransplant, Autografts, Autologous Transplant, Transplants, Autologous, Autograft, Autogenous graft, Autologous graft, Autoplast, Autograft (substance), Autograft -RETIRED-
Spanish autotrasplante, autoinjerto (concepto no activo), autoplastia, autoinjerto (sustancia), autoinjerto, injerto autógeno, injerto autólogo
Czech autologní štěp, autotransplantát
French Greffes autologues, Transplants autologues, Autogreffes, Autotransplants
German Autologe Transplantate, Autotransplantate
Italian Trapianti autologhi, Autoinnesti, Autotrapianti
Norwegian Autografter, Autotransplantater, Transplantater fra samme individ, Autologe transplantater
Russian AUTOTRANSPLANTATY, АУТОТРАНСПЛАНТАТЫ