Lung Transplantation in Cystic Fibrosis

Aka: Lung Transplantation in Cystic Fibrosis

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II. Indications for transplant referral in Cystic Fibrosis

  1. FEV1 30% or less
  2. Mitigating factors
    1. Severe Malnutrition
    2. Cor Pulmonale
    3. Marked Exercise intolerance
    4. Frequent respiratory exacerbations
    5. Increasingly resistant Pseudomonas
    6. Young age

III. Contraindications to Transplantation

  1. Severe Scoliosis
  2. Renal Insufficiency
  3. Biliary Cirrhosis
  4. Poorly controlled Diabetes Mellitus
  5. History of noncompliance

IV. Prognosis

  1. Survival with transplant
    1. One year survival: 65%
    2. Two year survival: 58%
  2. Survival without transplant (FEV1 < 30%)
    1. Two Year survival: 50%

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