II. Epidemiology

  1. ICU patients (most common)
  2. Patients on Backboard in Emergency Department
  3. Children more often affected

III. Risk Factors

  1. Children
  2. Infusion dose >3-4 mg/kg/hour
  3. Infusion duration >12-24 hours (esp. >48 hours)
  4. Risk may be increased in patients with underlying mitochondrial disorders or Muscle disorders

IV. Pathophysiology

  1. Propofol infusion results in mitochondrial respiration arrest (similar to cyanide Poisoning)

V. Risk Factors

  1. Young patients
  2. Sepsis
  3. Concurrent pressor or Glucocorticoid administration

VII. Management

  1. Supportive care
  2. Carbohydrate substitution Dialysis and ECMO have been used
  3. Hemodialysis if Acute Renal Failure occurs

VIII. Prognosis

  1. High mortality rate

IX. References

  1. Herbert (2012) EM:RAP 12(1): 3
  2. Claudius in Herbert (2019) EM:Rap 19(4): 12

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Related Studies

Ontology: Propofol infusion syndrome (C1328409)

Concepts Finding (T033)
Italian Sindrome da infusione di propofol
Japanese プロポフォール注入症候群, プロポフォールチュウニュウショウコウグン
Czech Syndrom po infuzi propofolu
Hungarian Propofol infusio syndroma
English Propofol infusion syndrome
Portuguese Síndrome de infusão de propofol
Spanish Síndrome de infusión con propofol
Dutch propofolinfuussyndroom
French Syndrome lié à une perfusion de propofol
German Propofol-Infusions-Syndrom