II. Epidemiology
- ICU patients (most common)
- Patients on Backboard in Emergency Department
- Children more often affected
III. Risk Factors
- Children
- Infusion dose >3-4 mg/kg/hour
- Infusion duration >12-24 hours (esp. >48 hours)
- Risk may be increased in patients with underlying mitochondrial disorders or Muscle disorders
IV. Pathophysiology
V. Risk Factors
- Young patients
- Sepsis
- Concurrent pressor or Glucocorticoid administration
VI. Signs
VII. Management
- Supportive care
- Carbohydrate substitution Dialysis and ECMO have been used
- Hemodialysis if Acute Renal Failure occurs
VIII. Prognosis
- High mortality rate
IX. References
- Herbert (2012) EM:RAP 12(1): 3
- Claudius in Herbert (2019) EM:Rap 19(4): 12
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Related Studies
| Concepts | Finding (T033) |
| Italian | Sindrome da infusione di propofol |
| Japanese | プロポフォール注入症候群, ﾌﾟﾛﾎﾟﾌｫｰﾙﾁｭｳﾆｭｳｼｮｳｺｳｸﾞﾝ |
| Czech | Syndrom po infuzi propofolu |
| Hungarian | Propofol infusio syndroma |
| English | Propofol infusion syndrome |
| Portuguese | Síndrome de infusão de propofol |
| Spanish | Síndrome de infusión con propofol |
| Dutch | propofolinfuussyndroom |
| French | Syndrome lié à une perfusion de propofol |
| German | Propofol-Infusions-Syndrom |
