II. Epidemiology

  1. Onset in middle age
  2. Rarely occurs at Puberty in familial forms
  3. Intraoral Sebaceous Hyperplasia (Fordyce Spots) are seen in 1% of newborns

III. Pathophysiology

  1. Composed of mature, enlarged Sebaceous Glands with dilated duct

IV. Causes

  1. Most cases idiopathic with aging
  2. Cyclosporine
  3. Hemodialysis

V. Signs

  1. Characteristics
    1. Pale yellow color
    2. Soft, shiny dome-shaped Papules
    3. May be centrally umbilicated
    4. Usually 2-4 mm in size
    5. May appear
  2. Dermoscopy
    1. Cauliflower-like multiple yellow lobules surrounding Hair Follicles
  3. Distribution
    1. Forehead, Cheeks, Nose
    2. Vulva

VI. Labs

  1. Biopsy only lesions suspicious for Basal Cell Carcinoma

VII. Differential Diagnosis

  1. Basal Cell Carcinoma
    1. Basal cell is typically more red or pink than the yellow Sebaceous Hyperplasia
    2. Surface vessels are haphazardly positioned (under magnification)
      1. Contrast with inter-lobular vessels only in Sebaceous Hyperplasia

VIII. Management

  1. Biopsy if suspect Basal Cell Carcinoma
  2. Cosmetic removal
    1. Shave excision
    2. Electrodesiccation
    3. Cryosurgery
    4. Laser ablation
    5. Topical bichloracetic acid
    6. Avoid curettage due to scarring
    7. Multiple lesions have been treated with Accutane (oral Isotretinoin)

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Related Studies

Ontology: Senile sebaceous gland hyperplasia (C0263435)

Concepts Disease or Syndrome (T047)
SnomedCT 19845004
English Senile sebaceous gland hyperplasia, Senile sebaceous gland hyperplasia (disorder), Senile sebaceous gland hyperplasia, NOS
Spanish hiperplasia senil de las glándulas sebáceas (trastorno), hiperplasia senil de las glándulas sebáceas

Ontology: Sebaceous hyperplasia (C0406484)

Concepts Disease or Syndrome (T047)
SnomedCT 238748009
Italian Iperplasia sebacea
Japanese 脂腺過形成, シセンカケイセイ
Czech Sebaceózní hyperplazie
English sebaceous hyperplasia (diagnosis), sebaceous hyperplasia, Sebaceous gland hyperplasia, Benign seborrheic hyperplasia, Benign seborrhoeic hyperplasia, Sebaceous hyperplasia (disorder), Sebaceous Hyperplasia, Sebaceous hyperplasia
Spanish hiperplasia seborreica benigna, hiperplasia seborréica benigna, hiperplasia sebácea (trastorno), hiperplasia sebácea, Hiperplasia sebácea
Hungarian Faggyúmirigy hyperplasia
Portuguese Hiperplasia sebácea
Dutch talghyperplasie
French Hyperplasie sébacée
German Talgdruesenhyperplasie