Ectopic Sebaceous Glands

Aka: Ectopic Sebaceous Glands, Fordyce's Granules, Fordyce's Disease, Intraoral Sebaceous Hyperplasia, Fordyce Spots, Congenital Sebaceous Hyperplasia

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II. Epidemiology

  1. May ocur at any age
  2. Incidence: 1% of newborns (Congenital Sebaceous Hyperplasia)

III. Pathophysiology

  1. Normal, benign variant of ectopic Sebaceous Gland hyperplasia on Buccal mucosa
  2. Lesions contain sebaceous lobules
  3. Lesions are not associated with Hair Follicles
  4. In newborns, lesions are associated with increased maternal androgen levels

IV. Signs

  1. Characteristics
    1. Yellow to white, pinpoint (1 to 4 mm), submucosal Papules
    2. Lesions are asymptomatic
    3. May be clustered or isolated
    4. May have central umbilication
    5. Fluid filled Vesicles
  2. Distribution
    1. Buccal mucosa
    2. Vermillion border of lips
    3. Genital mucosa (older children or adults)

V. Differential Diagnosis

  1. Bohn Nodule (Epstein's Pearls, Dental Lamina Cysts)
  2. Neonatal Herpes Simplex
  3. Mucocele
  4. Condyloma acuminata

VI. Course

  1. Congenital Sebaceous Hyperplasia (newborns)
    1. Resolves by a few weeks of life

VII. References

  1. Trang (2023) Am Fam Physician 108(2): 201-2 [PubMed]

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