Oral Erythroplakia

Aka: Oral Erythroplakia, Erythroplakia, Erythroplasia, Speckled Leukoplakia, Erythroleukoplakia

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II. Epidemiology

  1. Much less common than Leukoplakia
  2. More predictive of neoplasm than Leukoplakia
    1. 90% of early carcinomas appear as Erythroplakia (severe dysplasia, carcinoma in situ or carcinoma)

III. Signs: Erythematous counterpart to Leukoplakia

  1. Red, velvet-like lesion (smooth or pebbly surface)
  2. Speckled Leukoplakia (Erythroleukoplakia) may also be present
    1. White patches on periphery of Erythroplakia

IV. Differential Diagnosis

  1. Epithelial dysplasia
  2. Squamous Cell Carcinoma

V. Management

  1. Biopsy if lesion persists >2 weeks

VI. Prevention

  1. Tobacco Cessation
  2. Alcohol cessation

VII. References

  1. Randall (2022) Am Fam Physician 105(4): 369-76 [PubMed]
  2. Weinberg (2002) Am Fam Physician 65:1379-86 [PubMed]

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