II. Indications
III. Mechanism
- Cyclosporine is a Calcineurin Inhibitor with Immunosuppression and antiinflammatory properties (esp. inhibits T-Helper Cells)
- Improves tear production in autoimmune disorders (esp. Sjogren's Syndrome)
IV. Preparations
-
Cyclosporine A 0.05% (Restasis) use 1 drop in each eye every 12 hours
- Wait for 10 minutes before inserting Contact Lenses after applying drop
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restasis (on 10/19/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
RESTASIS 0.05% EYE EMULSION | Generic | $3.93 each |
RESTASIS MULTIDOSE 0.05% EYE | $112.47 per ml |
Ontology: Cyclosporine 0.5 MG/ML Ophthalmic Suspension (C1168858)
Concepts | Clinical Drug (T200) |
SnomedCT | 407103000 |
English | CYCLOSPORINE 0.05 % OPHTHALMIC DROPPERETTE, SINGLE-USE DROP DISPENSER, CYCLOSPORINE@0.05 %@OPHTHALMIC@DROPPERETTE, SINGLE-USE DROP DISPENSER, Cyclosporine 0.5 MG/ML Ophthalmic Suspension, CYCLOSPORINE 0.05% (PF) OPH EMUL 0.4ML, cyclosporine 0.05 % Ophthalmic Suspension, CYCLOSPORINE 0.05% OPHTHALMIC DROPPERETTE, SINGLE-USE DROP DISPENSER, CYCLOSPORINE@0.05%@OPHTHALMIC@DROPPERETTE, SINGLE-USE DROP DISPENSER, CYCLOSPORINE 0.05% DROPPERETTE, SINGLE-USE DROP DISPENSER, CYCLOSPORINE @ 0.05% @ DROPPERETTE, SINGLE-USE DROP DISPENSER, CYCLOSPORINE 0.05% (PF) EMULSION,OPH,0.4ML [VA Product], Cyclosporine 0.05% Ophthalmic drops, emulsion, cycloSPORINE 0.05 % Ophthalmic Suspension, cycloSPORINE 0.5 MG/ML Ophthalmic Suspension, Cyclosporine 0.05% Ophthalmic Emulsion, Cyclosporine (Ophth) Emulsion 0.05%, Cyclosporine ophthalmic emulsion 0.05% (product), Cyclosporine ophthalmic emulsion 0.05%, cycloSPORINE ophthalmic 0.05% ophthalmic emulsion, CYCLOSPORINE 0.05% (PF) EMULSION,OPH,0.4ML |
Spanish | ciclosporina, 0,05%, emulsión oftálmica (producto), ciclosporina, 0,05%, emulsión oftálmica |
Ontology: Restasis (C1170584)
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
English | Restasis, restasis |
Ontology: Cyclosporine Ophthalmic Emulsion (C2699534)
Definition (NCI) | An topical ophthalmic formulation containing cyclosporine, an undecapeptide produced by the fungus Beauveria nivea, with immunosuppressant and anti-inflammatory activities. The exact therapeutic mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. |
Concepts | Pharmacologic Substance (T121) |
English | Cyclosporine Ophthalmic Emulsion |