II. Indications
-
Open Angle Glaucoma
- Second-line agent for patients unable to tolerate topical Beta Blocker or as adjunctive agent
-
Narrow Angle Glaucoma
- Acetazolamide (Diamox) IV is used in emergent management
- Dorzolamide may also be used
III. Contraindications
IV. Mechanism
- Inhibits bicarbonate formation in the ciliary body
- Results in decreased aqueous production (lowers IOP 15-20%)
V. Medications (orange cap)
- Topical
- Dorzolamide (Trusopt) 2%, 1 drop three times daily
- Brinzolamide (Azopt) 1%, 1 drop three times daily
- Available as combination with Brimonidine (Simbrinza)
- Systemic
- Methazolamide (Neptazane)
- Acetazolamide (Diamox)
- See Narrow Angle Glaucoma for protocol
VI. Efficacy
- Less effective than Intraocular Beta Blocker and Intraocular Prostaglandin
VII. Adverse Effects
- Topical
- Systemic
- Paresthesias in hands and face
- Malaise, Anorexia, and severe weight loss
- Hypokalemia
- Nephrolithiasis
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Related Studies
| dorzolamide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DORZOLAMIDE HCL 2% EYE DROPS | Generic | $1.23 per ml |
| DORZOLAMIDE-TIMOLOL 2%-0.5% | Generic | $1.63 each |
| DORZOLAMIDE-TIMOLOL EYE DROPS | Generic | $1.14 per ml |
| brinzolamide (on 12/13/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| BRINZOLAMIDE 1% EYE DROPS | Generic | $15.73 per ml |
| azopt (on 7/27/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| AZOPT 1% EYE DROPS | Generic | $18.39 per ml |