II. Symptoms and Signs
-
General appearance
- Muscular male body habitus (e.g. Shoulder girdle)
- Android Obesity
- Miscellaneous Changes
- Deepening of voice
- Clitorimegaly
- Increased Libido
- Menstrual irregularity
- Endocrine changes
- Skin changes
- Hirsutism involving face, chin, chest and perineum
- Alopecia
- Acanthosis Nigricans (HAIR-AN Syndrome)
- Oily skin
- Acne Vulgaris
- Male sweat changes (malodorous perspiration)
III. Associated Conditions: Hyperandrogenic Syndromes
IV. Causes
V. Labs
-
Serum Testosterone (normally 20-80 ng/dl)
- Measure on 2 separate occasions
- Level <200: Hyperandrogenic chronic Anovulation
- Level >200: Assess for virilizing tumor
- Serum 17a-Hydroxyprogesterone (normally <2 ng/ml)
- Test >4 ng/ml suggests Congenital Adrenal Hyperplasia
- Check adrenocorticotropic stimulation test
-
Dehydroepiandrosterone sulfate (normal 250-300 ng/dl)
- DHEAS <700 ng/dl: Hyperandrogenic chronic Anovulation
- DHEAS >700 ng/dl: Adrenal tumor Secreting androgens
- Other labs to consider
- Dexamethasone Suppression Test (AM Serum Cortisol)
- Assess for Cushing's Syndrome
- Luteinizing Hormone and Follicle Stimulating Hormone
- Assess for ovarian tumors
- Lipid profile
- Lipids elevated in Hyperandrogenism
- Dexamethasone Suppression Test (AM Serum Cortisol)
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Related Studies
| Definition (NCI) | The abnormal development of male secondary sexual characteristics due to excessive androgens.(NICHD) |
| Definition (NCI_CTCAE) | A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male. |
| Definition (MSH) | Development of male secondary SEX CHARACTERISTICS in the FEMALE. It is due to the effects of androgenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs. |
| Definition (CSP) | abnormal possession of mature masculine somatic characteristics by a girl, woman, or prepubescent; may be present at birth or may appear first later in life, depending on its cause; it may be relatively mild (hirsutism) or severe; commonly the result of gonadal or adrenocortical dysfunction, or may be produced by androgenic therapy. |
| Concepts | Sign or Symptom (T184) |
| MSH | D014770 |
| SnomedCT | 190517002, 15160007 |
| English | Virilism, VIRILIZATION, MASCULINIZATION, VIRILISM, virilism, Virilism [Disease/Finding], virilization, virilisation, Virilisation, Masculinisation, Masculinization, Virilization (finding), masculinization, Masculinization, NOS, Virilization, NOS, Virilization |
| French | VIRILISME, Masculinisation, MASCULINISATION, VIRILISATION, Virilisme, Virilisation |
| Portuguese | VIRILISMO, Masculinização, MASCULINIZACAO, VIRILIZACAO, Virilismo, Virilização |
| Spanish | VIRILISMO, Masculinización, MASCULINIZACION, VIRILIZACION, masculinización, virilismo, virilización (hallazgo), virilización, Virilismo, Virilización |
| German | VIRILISMUS, MASKULINISIERUNG, VERMAENNLICHUNG, Maskulinisierung, Virilisierung, Virilismus, Vermännlichung |
| Dutch | masculinisatie, virilisatie, virilisme, Virilisme, Virilisatie |
| Italian | Mascolinizzazione, Virilizzazione, Virilismo |
| Japanese | ﾀﾞﾝｾｲｶ, 男性化, ビリリズム, 男性化症 |
| Czech | virilismus, Maskulinizace, Virilismus, Virilizace |
| Finnish | Virilismi |
| Russian | VIRILIZIRUIUSHCHII SINDROM, VIRILIZM, MASKULINIZM, ВИРИЛИЗИРУЮЩИЙ СИНДРОМ, ВИРИЛИЗМ, МАСКУЛИНИЗМ |
| Swedish | Virilism |
| Polish | Wirylizacja |
| Hungarian | Virilisatio, Virilismus, Masculinisatio |
| Croatian | VIRILIZACIJA, VIRILIZAM |
| Norwegian | Virilisme, Mannlige trekk hos kvinner |
Ontology: Hyperandrogenism (C0206081)
| Definition (MSH) | A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D017588 |
| SnomedCT | 237793004 |
| English | Hyperandrogenism, Hyperandrogenism [Disease/Finding], hyperandrogenism, Hyperandrogenisation syndrome, Hyperandrogenization syndrome (disorder), Hyperandrogenization syndrome |
| Dutch | hyperandrogenisme, Androgenisme, hyper-, Hyperandrogenisme |
| French | Hyperandrogénisme, Hyperandrogénie |
| Japanese | アンドロゲン過剰症, ｱﾝﾄﾞﾛｹﾞﾝｶｼﾞｮｳｼｮｳ |
| Swedish | Hyperandrogenism |
| Czech | hyperandrogenismus, Hyperandrogenismus |
| Finnish | Hyperandrogenismi |
| Russian | GIPERANDROGENIZM, ГИПЕРАНДРОГЕНИЗМ |
| Polish | Hiperandrogenizm |
| Hungarian | Hyperandrogenismus |
| Norwegian | Hyperandrogenisme |
| Spanish | hiperandrogenismo, síndrome de hiperandrogenización (trastorno), síndrome de hiperandrogenización, Hiperandrogenismo |
| German | Hyperandrogenismus |
| Italian | Iperandrogenismo |
| Portuguese | Hiperandrogenismo |
Ontology: Androgen excess (C0235461)
| Definition (NCI) | Excessive secretion of androgens from the adrenal glands or gonads. Clinical manifestations may include virilization.(NICHD) |
| Concepts | Finding (T033) |
| ICD10 | E28.1 |
| French | HYPERANDROGENISME, Effet excessivement androgène |
| English | ANDROGEN EXCESS EFFECT, Androgen excess, Androgen excess effect, androgens excess, excess androgen, androgen excess, Hyperandrogenism, Androgen Excess, excess; androgens, androgen; excess |
| Portuguese | HIPERANDROGENISMO, Efeito de excesso de androgénios |
| Dutch | androgeen surpluseffect, androgeen; overmaat, overmaat; androgenen, Overmaat aan androgenen |
| German | Androgenueberschuss Auswirkung, ANDROGENIS-ERSCHEINUNG, Ovarielle Dysfunktion: Androgenueberschuss |
| Italian | Effetto da eccesso di ormoni androgeni |
| Spanish | Efecto por exceso de andrógenos, ANDROGENOS, HIPERACTIVIDAD |
| Japanese | アンドロゲン過剰効果, ｱﾝﾄﾞﾛｹﾞﾝｶｼﾞｮｳｺｳｶ |
| Czech | Účinek nadbytku androgenů |
| Korean | 안드로겐 과다 |
| Hungarian | Túlzott androgén hatás |
Ontology: Hyperandrogenemia (C1299574)
| Concepts | Finding (T033) |
| SnomedCT | 371131009 |
| English | HYPERANDROGENEMIA, Hyperandrogenemia, Hyperandrogenaemia, Hyperandrogenemia (finding) |
| Czech | Hyperandrogenemie, Hyperandrogenémie |
| Dutch | hyperandrogenemie |
| French | Hyperandrogénie |
| German | Hyperandrogenaemie |
| Hungarian | Hyperandrogenemia, Hyperandrogenaemia |
| Italian | Iperandrogenemia |
| Japanese | ｺｳｱﾝﾄﾞﾛｹﾞﾝｹﾂｼｮｳ, 高アンドロゲン血症, ｺｳｱﾝﾄﾞﾛｹﾞﾝｹｯｼｮｳ |
| Portuguese | Hiperandrogenemia |
| Spanish | Hiperandrogenemia, hiperandrogenemia (hallazgo), hiperandrogenemia |
