II. Definition: Hair-AN Acronym

III. Pathophysiology

  1. Primary abnormality
    1. Insulin Resistance causes increased Insulin
  2. Secondary abnormality
    1. Excess androgen secretion from ovaries

IV. Associated Conditions

VI. Labs

VII. Management

  1. General Measures
    1. Weight loss
    2. See Hirsutism
  2. Gonadotropin suppression
    1. Oral Contraceptives (low Androgenic Activity)
      1. Desogestrel (Desogen)
      2. Norgestimate (Ortho-Cyclen)
    2. Anti-androgens
      1. Spironolactone (Aldactone) 50 to 100 mg po bid
      2. Flutamide (Eulexin)
        1. Risk of hepatotoxicity
      3. Finasteride (Proscar) 5 mg per day
  3. Insulin Resistance Modifier
    1. Glucophage (Metformin) 500 - 850 mg PO qd to bid

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Related Studies

Ontology: HAIR-AN syndrome (C1963745)

Concepts Disease or Syndrome (T047)
MSH C537629
Spanish Síndrome HAIR-AN
French Syndrome HAIR-AN
Dutch HAIR-AN-syndroom
Portuguese Síndrome de HAIR-AN
German HAIR-AN Syndrom
Italian Sindrome HAIR-AN
Japanese HAIR−AN症候群, HAIRANショウコウグン
Czech Syndrom HAIR-AN
English HAIR-AN syndrome, Hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN), Hyperandrogenic, insulin-resistant acanthosis nigricans syndrome
Hungarian HAIR-AN syndroma