II. Definition: Hair-AN Acronym
- Hyperandrogenism (HA)
- Insulin Resistance (IR)
- Acanthosis Nigricans (AN)
III. Pathophysiology
- Primary abnormality
- Insulin Resistance causes increased Insulin
- Secondary abnormality
- Excess androgen secretion from ovaries
IV. Associated Conditions
V. Differential Diagnosis
VI. Labs
-
General lab testing
- Complete Blood Count (CBC)
- Thyroid Stimulating Hormone (TSH)
- Serum Prolactin
- Serum Electrolytes (Chem7)
- Labs associated with Insulin Resistance
- Fasting Serum Glucose
- Consider Glucose Tolerance Test
- Labs associated with Androgen Excess
- See Hyperandrogenism
VII. Management
-
General Measures
- Weight loss
- See Hirsutism
- Gonadotropin suppression
- Oral Contraceptives (low Androgenic Activity)
- Anti-androgens
- Spironolactone (Aldactone) 50 to 100 mg po bid
- Flutamide (Eulexin)
- Risk of hepatotoxicity
- Finasteride (Proscar) 5 mg per day
-
Insulin Resistance Modifier
- Glucophage (Metformin) 500 - 850 mg PO qd to bid
Images: Related links to external sites (from Bing)
Related Studies
| Concepts | Disease or Syndrome (T047) |
| MSH | C537629 |
| Spanish | Síndrome HAIR-AN |
| French | Syndrome HAIR-AN |
| Dutch | HAIR-AN-syndroom |
| Portuguese | Síndrome de HAIR-AN |
| German | HAIR-AN Syndrom |
| Italian | Sindrome HAIR-AN |
| Japanese | ＨＡＩＲ−ＡＮ症候群, HAIRANｼｮｳｺｳｸﾞﾝ |
| Czech | Syndrom HAIR-AN |
| English | HAIR-AN syndrome, Hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN), Hyperandrogenic, insulin-resistant acanthosis nigricans syndrome |
| Hungarian | HAIR-AN syndroma |
