Anti-Mullerian Hormone

Aka: Anti-Mullerian Hormone, Anti Mullerian Hormone, Mullerian-Inhibiting Hormone, AMH

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II. Physiology

  1. Anti-Mullerian Hormone (AMH) is secreted by granulosa cells in follicles (small antral and preantral)
    1. AMH increases from birth to age 25 years
    2. After peaking, AMH gradually decreases until Menopause
  2. Considered a stable marker of ovarian reserve
    1. Menstrual Cycle may result in some cyclical variation (esp. young women)
    2. Oral Contraceptives may also decrease AMH levels

III. Indications

  1. Marker of ovarian reserve
    1. Premature Ovarian Failure confirmation
    2. Predict Menopause onset
  2. Ovarian Tumor Marker
    1. Folliculoma

IV. Interpretation

  1. AMH <1 suggests decreased ovarian reserve

V. Calculations: Prediction of Age at Menopause

  1. Original Tehrani et. al. Model Calculation (using python, numpy)
    1. MenopauseAge = np.power(-np.log(0.5),0.060388) * exp(3.18019 + 0.1608897 * amh + 0.016068 * age)
  2. Simplified Calculation (approximates the formula above, for age 25 years old and older)
    1. MenopauseAge = 35.2 + 0.7*((age-25)+(amh*10))
    2. Python code demonstrating a comparison of the simplified model versus the original model (Jupyter Lab)
      1. MenopauseAgePredictor.html

VI. References

  1. David S. Johnson, MD email communication 3/2/2020
  2. kruszynska (2017) Prz Menopauzalny 16(2): 47-50 +PMID:28721129 [PubMed]
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509971/
  3. Tehrani (2013) J Clin Endocrinol Metab 98(2):729-35 +PMID:23316087 [PubMed]
    1. https://academic.oup.com/jcem/article/98/2/729/2833229

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Related Studies

Ontology: mullerian-inhibiting hormone (C0066928)

Definition (MSH) A glycoprotein that causes regression of MULLERIAN DUCTS. It is produced by SERTOLI CELLS of the TESTES. In the absence of this hormone, the Mullerian ducts develop into structures of the female reproductive tract. In males, defects of this hormone result in persistent Mullerian duct, a form of MALE PSEUDOHERMAPHRODITISM.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D054304
SnomedCT 53252001
LNC LP34629-3, MTHU017479
English Antimullerian Hormone, Mullerian Inhibiting Hormone, Mullerian Inhibiting Factor, Muellerian Inhibiting Hormone, Mullerian-Inhibiting Factor, Anti Mullerian Hormone, Anti Mullerian Factor, ANTIMULLERIAN HORMONE, Anti-Mullerian Factor, Mullerian-Inhibitory Substance, Mullerian Inhibitory Substance, Mullerian Inhibiting Substance, Mullerian-Inhibiting Hormone, Anti-Mullerian Hormone, Mullerian Regression Factor, Anti-Mullerian Hormone [Chemical/Ingredient], Mullerian inhibiting factor, Mullerian inhibiting hormone, Anti-Mullerian hormone, Mullerian inhibiting substance, Mullerian regression factor, Mullerian regression factor (substance), mullerian-inhibiting hormone
Portuguese Hormônio Inibidor Mülleriano, Hormônio Antimülleriano
Finnish anti-Müller-hormoni
French Facteur anti-mullérien, Hormone antimullérienne, Hormone anti-mullérienne, Facteur antimullérien, Hormone anti-müllérienne, HAM (Hormone AntiMullérienne)
German Anti-Müller-Faktor, Müller-inhibierender Faktor, Müller-inhibierendes Hormon, Müller-inhibierende Substanz, Anti-Müller-Hormon, Müllerscher Regressionsfaktor
Italian Sostanza antimulleriana, Ormone antimulleriano, Fattore antimulleriano, Ormone inibente lo sviluppo delle strutture femminile mulleriane
Russian АНТИ-МЮЛЛЕРОВ ГОРМОН, ГОРМОН, ИНГИБИРУЮЩИЙ РАЗВИТИЕ МЮЛЛЕРОВЫХ ПРОТОКОВ, ANTI-MIULLEROV GORMON, MIULLEROVYKH PROTOKOV RAZVITIE INGIBIRUIUSHCHII GORMON, ANTIMIULLEROV GORMON, МЮЛЛЕРОВЫХ ПРОТОКОВ РАЗВИТИЕ ИНГИБИРУЮЩИЙ ГОРМОН, АНТИМЮЛЛЕРОВ ГОРМОН, GORMON, INGIBIRUIUSHCHII RAZVITIE MIULLEROVYKH PROTOKOV
Japanese ミュラー管退縮物質, 抗ミュラー管ホルモン, 抗Mueller管ホルモン, ミュラー管抑制物質, ミュラー管抑制因子, ミュラー管退行因子
Czech müllerský inhibiční hormon, antimüllerický hormon
Spanish Hormona Inhibidora Mülleriana, hormona anti-mulleriana, factor de inhibición mulleriano, hormona de inhibición mulleriana, Hormona Antimülleriana, Hormona Inhibidora de los Conductos de Müller, Hormona Anti-Mülleriana, Hormona Inhibidora de los Conductos Paramesonéfricos, factor de regresión mulleriano (sustancia), factor de regresión mulleriano
Swedish Anti-Mylleriskt hormon
Polish Hormon regresji przewodów Mullera
Norwegian Antimüllerhormon, AMH
Derived from the NIH UMLS (Unified Medical Language System)

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