II. Pathophysiology
- GHB Dependence is rare due to rapid elimination
- GHB Dependence may occur with excessive use
- Frequent dosing (q1-3 hours around the clock)
- Chronic use
III. Symptoms: Withdrawal
- Early symptoms
- Later symptoms
- Agitation
- Vivid Hallucinations
- Combative behavior
- Disorientation
- Associated Symptoms: Autonomic Instability
- Tachycardia
- Hypertension
- Tremor
- Diaphoresis
IV. Differential Diagnosis
V. Labs
VI. Management
- Agitation may require restraints
- Four point Physical Restraints
- See also Chemical Restraints
- Symptomatic management
- Sedation
- Benzodiazepine
- Barbiturate
