II. Pathophysiology

  1. Sources
    1. Spontaneous rupture of alveolus or bleb
    2. Tracheobronchial Injury (Trauma)
    3. Boerhaave's Syndrome (Esophageal Rupture)
  2. Results from increased pressure gradient
    1. Negative (Inhalation)
    2. Positive (Valsalva)
  3. Air tracks along vessels and Bronchi
  4. Air coalesces in mediastinum

III. Causes

  1. Secondary Pneumomediastinum (may be life-threatening)
    1. Tracheobronchial Injury (Trauma, Foreign Body Aspiration)
    2. Boerhaave's Syndrome (Esophageal Rupture, sharp Foreign Body Ingestion)
  2. Spontaneous Pneumomediastinum (tends to be benign)
    1. Inhalation Drug Use (e.g. Huffing)
      1. Inhalation Drug Users may perform action similar to Muller Maneuver
      2. Forced inspiration against a closed mouth and nose (opposite Valsalva Maneuver)
    2. Asthma
    3. Coughing
    4. Vomiting
    5. Weight lifting
    6. Vaginal Delivery
    7. Mechanical Ventilation

IV. Symptoms

  1. Sore Throat
  2. Dyspnea
  3. Pleuritic Chest Pain
    1. Worse with lying
    2. Better with sitting

V. Signs

  1. Subcutaneous Emphysema
  2. Hamman's Crunch (50%)
    1. Sound heard synchronous with heart beat

VI. Differential Diagnosis

VII. Imaging

  1. Chest XRay
    1. As many as 50% Pneumomediastinum cases are missed on PA Chest XRay
      1. Observe for a stripe of air extending superiorly from hilum, parallel to mediastinum
    2. Review Lateral Chest XRay carefully
    3. Consider lateral neck XRay
      1. Air tracks between posterior pharyngeal wall and Vertebrae
      2. Air is more easily seen on this view, than Chest XRay
    4. Named Signs
      1. Naclerio V Sign
        1. Sharp, well demarcated "V" along the left heart border and left diaphragm
      2. Continuous Diaphragm Sign
        1. Air below the heart results in a continuous line across the diaphragm
  2. Chest CT
    1. Small Pneumomediastinum is not uncommon on Trauma chest CT

VIII. Management

  1. Primary Pneumomediastinum (e.g. due to excessive coughing, Asthma)
    1. Often a benign, incidental finding on CT Imaging
  2. Secondary Pneumomediastinum (e.g. Tracheobronchial Injury, Esophageal Rupture)
    1. Serious, potentially life threatening finding
    2. Intensive Care Unit Admission and thoracic surgery Consultation

IX. Complications

  1. Tension Pneumomediastinum (rare)
    1. Presents with Hypotension
    2. Acute stabilization requires suprasternal notch Blunt Dissection (relieves tension)

X. References

  1. Swadron (2019) Pulmonology 2, CCME Board Review, accessed 6/18/2019

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Related Studies

Ontology: Mediastinal Emphysema (C0025062)

Definition (NCI_NICHD) Mediastinal emphysema is a condition in which air is present in the mediastinum. It can result from physical trauma or other situations that lead to air escaping from the lungs, airways or bowel into the chest cavity.
Definition (NCI) The presence of air in the mediastinum. It is caused by injury, most often esophageal or intestinal perforation.
Definition (MSH) Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.
Concepts Pathologic Function (T046)
MSH D008478
ICD10 J98.2
SnomedCT 155627006, 390899006, 196144009, 266411000, 16838000
English Emphysema, Mediastinal, Emphysemas, Mediastinal, Mediastinal Emphysema, Mediastinal Emphysemas, Pneumomediastinum, mediastinal emphysema (diagnosis), mediastinal emphysema, Mediastinal Emphysema [Disease/Finding], pneumomediastinum, Pmeumomediastinum, Mediastinal emphysema, Mediastinal emphysema (disorder), emphysema; mediastinal, mediastinal; emphysema, Mediastinal emphysema [Ambiguous]
Dutch mediastinaal emfyseem, emfyseem; mediastinaal, mediastinaal; emfyseem, pneumomediastinum, Emfyseem, mediastinum-, Mediastinumemfyseem, Pneumomediastinum
German mediastinales Emphysem, Emphysem, Mediastinal-, Mediastinalemphysem, Pneumomediastinum
Italian Enfisema del mediastino, Pneumomediastino, Enfisema mediastinico
Portuguese Enfisema do mediastino, Pneumomediastino, Enfisema Mediastínico
Spanish Enfisema mediastínico, enfisema mediastinal, neumomediastino, enfisema del mediastino (trastorno), enfisema del mediastino, enfisema mediastínico, Pneumomediastino, Enfisema Mediastínico, Neumomediastino
Japanese 気縦隔症, ジュウカクキシュ, キジュウカクショウ, 気腫-縦隔, 縦隔気腫
Swedish Mediastinalt emfysem
Czech mediastinum - emfyzém, pneumomediastinum, Pneumomediastinum, Mediastinální emfyzém
Finnish Välikarsinan ilmapöhö
Polish Odma śródpiersiowa
Hungarian Mediastinalis emphysema, Pneumomediastinum
Norwegian Mediastinalemfysem, Pneumomediastinum, Mediastinumemfysem, Emfysem, mediastinalt, Mediastinalt emfysem
French Pneumomédiastin, Emphysème du médiastin, Emphysème médiastinal

Ontology: Hamman's sign (C1532085)

Concepts Finding (T033)
SnomedCT 414377007
English Hamman sign, Hamman's sign (finding), Hamman's sign
Spanish signo de Hamman (hallazgo), signo de Hamman