II. Definitions
- Periostin
- Matricellular Protein (fasciclin family) associated with cell adhesion
- Encoded by the human POSTN gene
- Increased in Type 2 Asthma (Eosinophilic Asthma) correlated with airway inflammation and remodeling
III. Causes: Increased Periostin
- Severe Eosinophilic Asthma (T2 Asthma)
- Periostin is a marker of Allergic Asthma activity including airway inflammation and remodeling and longterm prognosis
- Associated with increased IL-4 and IL-13 activity in lung fibroblasts and airway epithelial cells
- Periostin triggers Eosinophil degranulation as well as the production of superoxide anions, TGF-B and CysLT from Eosinophils
- Periostin has higher baseline levels with certain subtypes of Eosinophilic Asthma (T2 Asthma)
IV. Causes: Decreased Periostin
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Related Studies
| Concepts | Amino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123) |
| MSH | C512835 |
| English | periostin protein, human, osteoblast-specific factor 2, human, POSTN protein, human, OSF-2 protein, human, periostin, osteoblast specific factor, human |
Ontology: Periostin Measurement (C3812270)
| Definition (NCI) | The determination of the amount of periostin present in a sample. |
| Definition (NCI_CDISC) | A measurement of the periostin in a biological specimen. |
| Concepts | Laboratory Procedure (T059) |
| English | Periostin, PERIOSTN, POSTN, OSF2, Osteoblast Specific Factor 2, Periostin Measurement |
