II. Definitions
- Periostin
- Matricellular Protein (fasciclin family) associated with cell adhesion
- Encoded by the human POSTN gene
- Increased in Type 2 Asthma (Eosinophilic Asthma) correlated with airway inflammation and remodeling
III. Causes: Increased Periostin
- Severe Eosinophilic Asthma (T2 Asthma)
- Periostin is a marker of Allergic Asthma activity including airway inflammation and remodeling and longterm prognosis
- Associated with increased IL-4 and IL-13 activity in lung fibroblasts and airway epithelial cells
- Periostin triggers Eosinophil degranulation as well as the production of superoxide anions, TGF-B and CysLT from Eosinophils
- Periostin has higher baseline levels with certain subtypes of Eosinophilic Asthma (T2 Asthma)