II. Causes
- Renal Failure
- Dehydration
- Addison's Disease
- Hypervitaminosis D
- Hypoparathyroid
- Magnesium Deficiency
- Milk-Alkali Syndrome
- Transfusions
- Hemolysis
- Sarcoidosis
- Bone metastases
- Myelogenous Leukemia
III. Evaluation: Renal Failure
-
Chronic Renal Failure
- Increased phosphate when GFR falls below 20 ml/min
- Usually Phosphate in 5-10 mg/dl range
-
Acute Renal Failure
- Especially in oliguric or hypercatabolic forms
- Highest in:
- Myoglobinuric Acute Tubular Necrosis
- Surgery
- Trauma
IV. Evaluation: Normal Renal Function
- Check Urinary phosphate excretion (Urine pHosphate)
- Increased Urine pHosphate: over 1500 mg/dl
- Endogenous source
- Cytotoxins
- Rhabdomyolysis
- Malignant hyperpyrexia (Fever)
- Exogenous source
- Endogenous source
- Normal Urine pHosphate: Under 1500mg/dl
- Increased reabsorption
- Hyperparathyroidism
- Menopause
- Extracellular Fluid Volume contraction
- Tumoral calcinosis
- Increased reabsorption
V. Management
-
Antacid binding gel: Aluminum hydroxide (AlternaGel)
- Dose 600 mg/5 ml, 5 ml qid with meals and at bedtime
- Low Phosphate diet
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Related Studies
| Definition (NCI) | Abnormally high level of phosphate in the blood. |
| Definition (MSH) | A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D054559 |
| SnomedCT | 20165001 |
| English | HYPERPHOSPHATAEMIA, HYPERPHOSPHATEMIA, Hyperphosphatemia, Hyperphosphatemias, hyperphosphatemia, hyperphosphatemia (diagnosis), Hyperphosphatemia [Disease/Finding], hyperphosphataemia, Hyperphosphatemia (disorder), Hyperphosphataemia |
| Japanese | 高リン酸塩血症, ｺｳﾘﾝｻﾝｴﾝｹﾂｼｮｳ, ｺｳﾘﾝｻﾝｴﾝｹｯｼｮｳ |
| Portuguese | Hiperfosfatemia, HIPERFOSFATEMIA |
| Spanish | Hiperfosfatemia, HIPERFOSFATEMIA, hiperfosfatemia (trastorno), hiperfosfatemia |
| Finnish | Hyperfosfatemia |
| French | Hyperphosphatémie, HYPERPHOSPHATEMIE |
| German | Hyperphosphatämie, HYPERPHOSPHATAEMIE, Hyperphosphataemie |
| Italian | Iperfosfatemia |
| Russian | ГИПЕРФОСФАТЕМИЯ, GIPERFOSFATEMIIA |
| Swedish | Hyperfosfatemi |
| Czech | Hyperfosfatemie, hyperfosfatémie |
| Polish | Hiperfosfatemia |
| Hungarian | Hyperphosphataemia |
| Norwegian | Hyperfosfatemi |
| Dutch | hyperfosfatemie |
