II. Pathophysiology
- Gram Negative Rod, pleomorphic
- Unlike Rickettsia
- Not obligate intracellular organism (but is facultative intracellular)
- Not anaerobic (Bartonella is obligate aerobe)
III. Associated Conditions
-
Cat Scratch Disease (Bartonella Henselae)
- Cats (>50% infected) transmit the infection via biting or clawing humans
- Cats acquire via fleas
- Self limited infection in immunocompetent hosts, for whom Antibiotics are limited to moderate cases
-
Bacillary Angiomatosis (Bartonella Henselae, Bartonella Quintana)
- Occurs in AIDS (CD4 Count <100 cells/mm3) and other Immunocompromised patients
- Vascular skin lesions similar to Kaposi's Sarcoma
- Dissemination to bone, CNS, mucous membranes as well as endocarditis and liver (Bacillary Peliosis)
-
Bacterial Endocarditis (Bartonella Henselae, Bartonella Quintana)
- Common cause of culture negative endocarditis (esp. in homeless, see Trench Fever below)
- Trench Fever (Bartonella Quintana, previously known as Rickettsia Quintana or Rochalimaea quintana)
- Affected millions in World War I
- Similar to Epidemic Typhus (Rickettsia prowazekii), as spread via Body Lice
- Seen in homeless or Alcoholic patients with Body Lice (which transmit infection)
- Presents with Relapsing Fever (every 5 days), Headaches, back and Leg Pain, Splenomegaly and variably, rash
- Complicated by bacteremia, Bacillary Angiomatosis or endocarditis
- Oroya Fever (Bartonella Bacilliformis)
- Infection endemic to Andes of Peru and Ecuador, transmitted by the sandfly
- Acute phase with Lymphadenopathy and severe Hemolytic Anemia
- Chronic phase (Peruvian Wart, Verruga Peruana) with red-purple Nodules in skin and mucous membranes
IV. References
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Definition (NCI_CDISC) | Any bacteria that is not assigned to the species level but can be assigned to the Bartonella genus level. |
Definition (NCI) | A genus of aerobic, Gram-negative, rod shaped bacterium assigned to the phylum Proteobacteria and the family Bartonellaceae. |
Definition (MSH) | A genus of gram-negative bacteria characteristically appearing in chains of several segmenting organisms. It occurs in man and arthropod vectors and is found only in the Andes region of South America. This genus is the etiologic agent of human bartonellosis. The genus Rochalimaea, once considered a separate genus, has recently been combined with the genus Bartonella as a result of high levels of relatedness in 16S rRNA sequence data and DNA hybridization data. |
Definition (CSP) | genus of gram negative bacteria characteristically appearing in chains of several segmenting organisms; occurs in man and arthropod vectors; etiologic agent of human bartonellosis, bacillary angiomatosis, trench fever and cat scratch disease; the genus Rochalimaea, once considered a separate genus, has been combined with the genus Bartonella as a result of high levels of relatedness. |
Concepts | Bacterium (T007) |
MSH | D001473 |
SnomedCT | 62496009, 112354006, 72051005, 243364004, 51988009 |
English | Bartonella, Rochalimaea, Genus Bartonella (organism), bartonella, rochalimaea, Grahamella (organism), Bartonella (organism), Rochalimaea, NOS, Rochalimea, NOS (organism), BARTONELLA, Bartonella Strong et al. 1915 (Approved Lists 1980) emend. Birtles et al. 1995, Bartonella Strong et al. 1915 (Approved Lists 1980) emend. Brenner et al. 1993, Grahamella (ex Brumpt 1911) Ristic and Kreier 1984, Grahmia, Rocha-Limae, Rochalimaea (Macchiavello 1947) Krieg 1961, Grahamella, Rochalimea, Bartonella, NOS, Grahamella, NOS, Rochalimea, NOS -RETIRED-, Genus Bartonella |
French | Rochalimaea, Bartonelle, Bartonella |
Swedish | Bartonella |
Czech | Bartonella |
Spanish | Bartonella (organismo), Grahamella, género Bartonella (organismo), Rochalimaea, género Bartonella, Rochalimaea - RETIRADO - (concepto no activo), Grahamella (concepto no activo), Rochalimaea - RETIRADO -, Bartonella |
Finnish | Bartonella |
Russian | BARTONELLEZ, VOZBUDITELI, BARTONELLY, BARTONELLA BACILIFORMIS, BARTONELLA, ROCHALIMAEA, БАРТОНЕЛЛЕЗ, ВОЗБУДИТЕЛИ, БАРТОНЕЛЛЫ |
Polish | Bartonella |
Japanese | バルトネラ, Bartonella属, バルトネラ属, ロカリメア, ロシャメリア |
Norwegian | Bartonella, Rochalimaea |
German | Bartonella, Rochalimaea |
Italian | Bartonella |
Dutch | Bartonella, Rochalimaea |
Portuguese | Bartonella, Rochalimaea |
Ontology: Bartonella Infections (C0004771)
Definition (NCI) | A gram-negative bacterial infection caused by Bartonella bacilliformis. It is transmitted by ticks, flies and mosquitoes. Signs and symptoms include fever, headache, muscle pain, enlargement of the lymph nodes and anemia. |
Definition (MSH) | Infections by the genus BARTONELLA. Bartonella bacilliformis can cause acute febrile anemia, designated Oroya fever, and a benign skin eruption, called verruga peruana. BARTONELLA QUINTANA causes TRENCH FEVER, while BARTONELLA HENSELAE is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY) and is also one of the causes of CAT-SCRATCH DISEASE in immunocompetent patients. |
Concepts | Disease or Syndrome (T047) |
MSH | D001474 |
ICD9 | 088.0 |
ICD10 | A44 , A44.9 |
SnomedCT | 17116008, 186824002, 187340003, 240623002, 240454008, 266123003 |
English | Bartonelloses, Bartonellosis, Carrion Disease, Carrion's Disease, Carrions Disease, Disease, Carrion, Infection, Bartonella, Infections, Bartonella, Disease, Carrion's, Infection, Rochalimaea, Infections, Rochalimaea, Rochalimaea Infection, Rochalimaea Infections, Bartonellosis, unspecified, [X]Bartonellosis, unspecified, BARTONELLA INFECT, ROCHALIMAEA INFECT, CARRION DIS, CARRIONS DIS, INFECT ROCHALIMAEA, INFECT BARTONELLA, bartonelliasis, Bartonella Infections, bartonellosis, Carrion's disease, bartonellosis (diagnosis), bartonellosis (Carrion's disease), Bartonella Infection, Bartonella Infections [Disease/Finding], carrion's disease, [X]Bartonellosis, unspecified (disorder), Carrion's disease (disorder), Rochalimaea infection (disorder), Bartonella infections, Bartonella infection, Guaitara fever, Rochalimaea infection, Bartonellosis (disorder), Bartonella; infection, infection; Bartonella, Bartonellosis (disorder) [Ambiguous] |
French | Infection à Rochalimaea, Bartonellose, Infections à Bartonella, Bartonelloses, Infections à Rochalimaea, Infections à bartonelles, Maladie de Carrion |
German | Rochalimaea-Infektion, Bartonellose, nicht naeher bezeichnet, Bartonellose, Infektionen durch Bartonella, Bartonellainfektionen, Bartonellosis, Carrion-Krankheit, Rochalimaeainfektionen |
Italian | Infezione da Rochalimaea, Infezioni da Rochalimaea, Malattia di Carrion, Bartonellosi, Infezioni da Bartonella |
Portuguese | Infecção por Rochalimaea, Bartonelose, Doença de Carrion, Infecções por Bartonella, Infecções por Rochalimae |
Spanish | Infección por Rochalimaea, [X]bartonelosis, no especificada (trastorno), enfermedad de Carrion, infección por Rochalimaea, infección por Rochalimaea (trastorno), enfermedad de Carrión, enfermedad de Carrión (trastorno), [X]bartonelosis, no especificada, bartonelosis (concepto no activo), bartonelosis (trastorno), bartonelosis, fiebre de Guaitara, Bartonelosis, Infecciones por Bartonella, Enfermedad de Carrion, Infecciones por Rochalimaea |
Japanese | ロシャリメア感染, バルトネラ感染, バルトネラカンセン, ロシャリメアカンセン, バルトネラショウ, カリオン病, バルトネラ感染症, Carrion病, オロヤ熱, バルトネラ症, ロカリメア感染症, ペルー疣症, ペルーいぼ病 |
Swedish | Bartonellainfektioner |
Czech | Bartonella - infekce, Infekce způsobené bartonelami, Infekce způsobená rochalimaeami, Bartonelóza |
Finnish | Bartonelloosit |
Russian | BARTONELLY INFEKTSII, KARRIONA BOLEZN', OROIA LIKHORADKA, BARTONELLEZ, ROCHALIMAEA INFEKTSII, BORODAVKA PERUANSKAIA, ROCHALIMAEA ИНФЕКЦИИ, БАРТОНЕЛЛЕЗ, БАРТОНЕЛЛЫ ИНФЕКЦИИ, БОРОДАВКА ПЕРУАНСКАЯ, КАРРИОНА БОЛЕЗНЬ, ОРОЯ ЛИХОРАДКА |
Korean | 상세불명의 바르토넬라증, 바르토넬라증 |
Polish | Bartoneloza, Zakażenie Bartonella, Gorączka Oroya, Brodawczakowatość peruwiańska, Zakażenie pałeczką Bartonella |
Hungarian | Bartonellosis, Bartonella fertőzések, Rochalimaea fertőzés |
Norwegian | Carrions sykdom, Rochalimaeainfeksjoner, Bartonellose, Bartonellainfeksjoner |
Dutch | Bartonella; infectie, infectie; Bartonella, Bartonellose, niet gespecificeerd, bartonellosis, Bartonellose, Bartonella-infectie, Bartonella-infecties, Bartonellosis, Carrion, ziekte van, Infectie, Bartonella-, Infecties, bartonella-, Rochalimaea-infectie, Ziekte van Carrion |
Ontology: Bartonellaceae (C0004772)
Definition (NCI) | A taxonomic family of pathogenic bacterium in the phylum Proteobacteria that includes the genus Bartonella. |
Definition (MSH) | A family of small gram-negative bacteria whose organisms are parasites of erythrocytes in man and other vertebrates and the etiologic agents of several diseases. |
Concepts | Bacterium (T007) |
MSH | D001475 |
SnomedCT | 115085000 |
English | Bartonellaceae, Bartonella group, Bartonellaceae Gieszczykiewicz 1939 (Approved Lists 1980) emend. Brenner et al. 1993, Family Bartonellaceae (organism), Family Bartonellaceae |
Swedish | Bartonellaceae |
Czech | Bartonellaceae |
Finnish | Bartonellaceae |
French | Bartonellacées, Bartonellaceae |
Polish | Bartonellaceae |
Norwegian | Bartonellaceae |
Spanish | familia Bartonellaceae (organismo), familia Bartonellaceae, Bartonellaceae |
German | Bartonellaceae |
Italian | Bartonellaceae |
Russian | BARTONELLACEAE |
Dutch | Bartonellaceae, Bartonellaceeën |
Portuguese | Bartonellaceae |
Ontology: Oroya Fever (C0029307)
Concepts | Disease or Syndrome (T047) |
MSH | D001474 |
ICD10 | A44.0 |
SnomedCT | 262461007, 240453002, 186824002, 17116008 |
English | Fever, Oroya, Carrion's disease, Oroya fever (diagnosis), Cat Scratch Fevers, Fevers, Cat Scratch, Cat Scratch Fever, Fever, Cat Scratch, Scratch Fever, Cat, Scratch Fevers, Cat, Oroya Fever, Cat scratch fever, Oroya fever, Infection by Bartonella bacilliformis, Infection by Bartonella bacilliformis (disorder), Oroya fever (disorder), Oroya; fever, fever; Oroya |
Portuguese | Febre de Oroya |
Spanish | Fiebre de Oroya, enfermedad de Carrion, fiebre de Oroya (trastorno), fiebre de Oroya, infección por Bartonella bacilliformis (trastorno), infección por Bartonella bacilliformis |
French | Fièvre d'Oroya |
German | Oroya-Fieber |
Italian | CSD, Febbre di Oroya, Malattia da graffio del gatto |
Norwegian | Oroya-feber, Katteklorfeber |
Dutch | Oroya; koorts, koorts; Oroya, Oroya-koorts |
Ontology: Bartonella quintana (bacteria) (C0035791)
Definition (NCI) | A species of Gram-negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is nonmotile, oxidase positive, indole and urease negative, and nonhemolytic. B. quintana causes trench fever. |
Definition (NCI_CDISC) | Any bacterial organism that can be assigned to the species Bartonella quintana. |
Definition (MSH) | A species of gram-negative bacteria in which man is the primary host and the human body louse, Pediculus humanus, the principal vector. It is the etiological agent of TRENCH FEVER. |
Concepts | Bacterium (T007) |
MSH | D018413 |
SnomedCT | 112355007, 103511001 |
LNC | LP14387-2 |
English | Rochalimaea quintana, Rickettsia quintana, Bartonella quintana, Bartonella quintana (bacteria), Burnetia (Rocha-limae) wolhynica, Rochalimaea quintana (Schmincke 1917) Krieg 1961 (Approved Lists 1980), Bartonella quintana (Schmincke 1917) Brenner et al. 1993, Rickettsia pediculi, Rickettsia weigli, Rickettsia wolhynica, Wolhynia qintanae, Rochalimea quintana (organism), ROCHALIMAEA QUINTANA, BARTONELLA QUINTANA, Bartonella quintana (organism), Rochalimea quintana -RETIRED- |
French | Rochalimaea quintana, Bartonella quintana, Rickettsia quintana |
Swedish | Bartonella quintana |
Czech | Bartonella quintana, Rochalimaea quintana, Rickettsia quintana |
Finnish | Bartonella quintana |
Italian | Rochalimaea quintana, Rickettsia quintana, Bartonella quintana |
Japanese | 五日熱リケッチア, ロシャリメア・クインターナ, ウォリニー熱リケッチア, 塹壕熱リケッチア, 塹壕熱ロカメリア, ざんごう熱リケッチア |
Polish | Rickettsia quintana, Rochalimaea quintana, Bartonella quintana |
Spanish | Rochalimaea quintana - RETIRADO -, Rochalimaea quintana - RETIRADO - (concepto no activo), Bartonella quintana (organismo), Bartonella quintana, Rickettsia quintana, Rochalimaea quintana |
Norwegian | Bartonella quintana, Rochalimaea quintana, Rickettsia quintana |
German | Bartonella quintana, Rickettsia quintana, Rochalimaea quintana |
Russian | BARTONELLA QUINTANA, RICKETTSIA QUINTANA, ROCHALIMAEA QUINTANA |
Dutch | Bartonella quintana, Rochalimaea quintana |
Portuguese | Bartonella quintana, Rickettsia quintana, Rochalimaea quintana |
Ontology: Trench Fever (C0040830)
Definition (MSH) | An intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by BARTONELLA QUINTANA and transmitted by the human louse. |
Concepts | Disease or Syndrome (T047) |
MSH | D014205 |
ICD9 | 083.1 |
ICD10 | A79.0 |
SnomedCT | 82214002 |
English | Fevers, Trench, Trench Fever, Trench Fevers, Fever, Trench, trench fever, five day fever, trench fever (diagnosis), trench fever (rickettsia quintana), fever due to Bartonella quintana, Rochalimaea quintana infection, Trench Fever [Disease/Finding], Quintan fever, Trench fever, Fever due to Rochalimaea quintana, Wolhynian fever, Febris quintata, Five day fever, Fever due to Bartonella quintana, Trench fever (disorder), His-Werner, febris; quintana, fever; quintan, fever; trench fever, fever; trench, fever; wolhynian, quintan; fever, quintana; febris, trench fever; fever, trench; fever, wolhynian fever, wolhynian; fever |
Dutch | Rochalimaea quintana-infectie, Wolhynia; koorts, febris; quintana, fever; trench, koorts; Wolhynia, koorts; loopgravenkoorts, koorts; vijfdedaagse, loopgravenkoorts; koorts, quintana; febris, trench; fever, vijfdedaagse; koorts, loopgravenkoorts, Koorts, loopgraven-, Loopgravenkoorts |
French | Infection à Rochalimaea quintana, Fièvre aigüe tibialgique, Fièvre aiguë tibialgique, Fièvre quintane, Fièvre des tranchées, Fièvre de Volhynie, Fièvre de Volkynee, Fièvre de la Meuse, Fièvre des cinq jours, Fièvre quinte |
German | Rochalimaea quintana-Infektion, Schuetzengrabenfieber, Febris quintana, Wolhynisches Fieber, Fünftagefieber |
Italian | Infezione da Rochalimaea quintana, Febbre delle trincee |
Portuguese | Infecção quintana por Rochalimaea, Febre das trincheiras, Febre das Trincheiras |
Spanish | Infección por Rochalimaea quintana, fiebre de las trincheras (trastorno), fiebre de las trincheras, fiebre de los cinco días, fiebre por Bartonella quintana, fiebre por Rochalimaea quintana, fiebre quintana, Fiebre de las trincheras, Fiebre de las Trincheras |
Japanese | ざんごう熱, ロシャリメア・クインターナ感染症, ザンゴウネツ, ロシャリメアクインターナカンセンショウ |
Swedish | Skyttegravsfeber |
Czech | zákopová horečka, volyňská horečka, Infekce způsobená Rochalimaea quintana, Zákopová horečka |
Finnish | Ampumahautakuume |
Russian | OKOPNAIA LIKHORADKA, LIKHORADKA OKOPNAIA, ЛИХОРАДКА ОКОПНАЯ, ОКОПНАЯ ЛИХОРАДКА |
Korean | 참호열 |
Polish | Gorączka okopowa, Gorączka wołyńska, Gorączka pięciodniowa, Gorączka mozelska |
Hungarian | Rochalimaea quintana fertőzés, lövészárok láz |
Norwegian | Febris quintana, Skyttergravsfeber |
Ontology: Verruga Peruana (C0042552)
Concepts | Disease or Syndrome (T047) |
MSH | D001474 |
ICD10 | A44.1 |
SnomedCT | 186824002, 240455009, 17116008 |
Portuguese | Verruga Peruana |
Spanish | Verruga Peruana, verruga peruana (trastorno), verruga peruana |
French | Verruga du Pérou, Pian hémorragique |
German | Verruga peruana, Verruca peruvana |
English | verruga peruana (diagnosis), verruga peruana, Verruga peruana, Verruga peruana (disorder), Verruga Peruana |
Italian | Verruca peruviana |
Norwegian | Verruga peruana |
Dutch | Verruga Peruana |
Ontology: Bartonella henselae (bacteria) (C0242631)
Definition (NCI_CDISC) | Any bacterial organism that can be assigned to the species Bartonella henselae. |
Definition (NCI) | A species of aerobic, Gram-negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is non-motile, oxidase, catalase, indole, and urease negative and is nonhemolytic. B. henselae is the primary agent of cat scratch disease. |
Definition (MSH) | A species of gram-negative bacteria that is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY). This organism can also be a cause of CAT-SCRATCH DISEASE in immunocompetent patients. |
Concepts | Bacterium (T007) |
MSH | D018416 |
SnomedCT | 112357004, 103510000 |
LNC | LP14083-7 |
English | Rochalimaea henselae, Bartonella henselae, Bartonella henselae (bacteria), bartonella henselae, rochalimaea henselae, Bartonella henselae (Regnery et al. 1992) Brenner et al. 1993, Rochalimaea henselae Regnery et al. 1992, Rochalimea henselae (organism), ROCHALIMAEA HENSELAE, BARTONELLA HENSELAE, Bartonella henselae (organism), Rochalimea henselae -RETIRED- |
French | Bartonella henselae, Rochalimaea henseleae |
Swedish | Bartonella henselae |
Czech | Bartonella henselae, Rochalimaea henselae |
Finnish | Bartonella henselae |
Italian | Rochalimaea henselae, Bartonella henselae |
Polish | Rochalimaea henselae, Bartonella henselae |
Spanish | Rochalimaea henselae - RETIRADO -, Rochalimaea henselae - RETIRADO - (concepto no activo), Bartonella henselae (organismo), Bartonella henselae, Rochalimaea henselae |
Norwegian | Bartonella henselae, Rochalimaea henselae |
German | Bartonella henselae, Rochalimaea henselae |
Russian | BARTONELLA HENSELAE, ROCHALIMAEA HENSELAE |
Dutch | Bartonella henselae, Rochalimaea henselae |
Portuguese | Bartonella henselae, Rochalimaea henselae |
Ontology: Bartonella bacilliformis (bacteria) (C0318324)
Definition (MSH) | The type species of the genus BARTONELLA, a gram-negative bacteria found in humans. It is found in the mountain valleys of Peru, Ecuador, and Southwest Columbia where the sandfly (see PHLEBOTOMUS) vector is present. It causes OROYA FEVER and VERRUGA PERUANA. |
Concepts | Bacterium (T007) |
MSH | D045503 |
SnomedCT | 51988009, 243352007 |
Swedish | Bartonella bacilliformis |
Czech | Bartonella bacilliformis |
English | Bartonella bacilliformis (bacteria), Bartonia bacilliformis, Bartonella bacilliformis (Strong et al. 1913) Strong et al. 1915, Bartonella bacilliformis (living organism) (organism), BARTONELLA BACILLIFORMIS, Bartonella bacilliformis, Bartonella bacilliformis (organism), Bartonella bacilliformis (living organism) [Ambiguous] |
Finnish | Bartonella bacilliformis |
Polish | Bartonella bacilliformis |
Spanish | Bartonella bacilliformis (organismo vivo), Bartonella bacilliformis (concepto no activo), Bartonella bacilliformis (organismo), Bartonella bacilliformis |
Norwegian | Bartonella bacilliformis |
French | Bartonella bacilliformis |
German | Bartonella bacilliformis |
Italian | Bartonella bacilliformis |
Russian | BARTONELLA BACILLIFORMIS |
Dutch | Bartonella bacilliformis |
Portuguese | Bartonella bacilliformis |
Ontology: Bartonellosis (& [Carrion's disease] or [Oroya fever] or [verruga peruana]) (C1541003)
Concepts | Disease or Syndrome (T047) |
SnomedCT | 186824002 |
English | Bartonellosis (& [Carrion's disease] or [Oroya fever] or [verruga peruana]) (disorder), Bartonellosis (& [Carrion's disease] or [Oroya fever] or [verruga peruana]) |