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Ontology:
Prazosin
(C0032912)
Definition (MSH)
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A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
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Definition (NCI)
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A synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin's effects are most pronounced in the large resistance vessels (i.e. arterioles) and result in a decrease in total systemic vascular resistance (SVR) without a rebound or reflex tachycardia. To a lesser extent, this agent also decreases the tone of the bladder sphincter, thereby allowing the opening of the bladder into the urethra and thus relieving the urinary conditions associated with benign prostatic hypertrophy.
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Definition (CSP)
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1-(4-amino-6,7-dimethoxy- 2-quinazolinyl) -4-(2-furoyl) piperazine.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D011224
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SnomedCT |
367555002, 387283005, 387433003, 76058001, 51505001 |
LNC |
LP18588-1, MTHU004704 |
English |
Furazosin, Prazosin, Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-, 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine, Prazosin [Chemical/Ingredient], PRAZOSIN, prazosin (medication), Furazosin (product), prazosin, Prazosin (product), Prazosin (substance), Furazosin (substance) |
Swedish |
Prazosin
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Czech |
prazosin
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Finnish |
Pratsosiini
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Russian |
PRAZOZIN, ADVERZUTEN, FURAZOZIN, PRATSIOL, АДВЕРЗУТЕН, ПРАЗОЗИН, ПРАТСИОЛ, ФУРАЗОЗИН |
Japanese |
プラゾシン, 塩酸プラゾシン, フラゾシン |
Italian |
Furazosina, Prazosina |
Spanish |
prazosina (producto), prazosín (producto), furazosín, furazosina, furazosín (producto), furazosina (sustancia), prazosina (sustancia), prazosina, prazosín, Furazosina, Prazosina |
Polish |
Prazosyna
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French |
Prazosine
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German |
Furazosin, Prazosin |
Portuguese |
Furazosin, Prazosina |
Ontology:
Terazosin
(C0076107)
Definition (NCI_NCI-GLOSS)
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A drug used to treat urinary problems caused by an enlarged prostate. It is also used to treat high blood pressure and is being studied in the treatment of other conditions. Terazosin relaxes muscle tissue in blood vessels and in the prostate. It is a type of alpha blocker.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C041226
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SnomedCT |
349914007, 129484001, 387068008 |
LNC |
LP101133-9, MTHU036183 |
English |
terazosin, Terazosin, Terazosin [Chemical/Ingredient], terazosine, TERAZOSIN, Terazosin (product), Terazosin (substance) |
Spanish |
terazosina (producto), terazosina (sustancia), terazosina |
Ontology:
Doxazosin
(C0114873)
Definition (MSH)
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A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
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Definition (NCI)
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A quinazoline with antihypertensive and antineoplastic properties. Doxazosin is an alpha-adrenergic antagonist that selectively inhibits alpha-1 adrenergic receptors. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia. Furthermore, doxazosin induces apoptosis in prostate cancer cells mediated through inhibition of protein kinase B (PKB)/Akt-signaling death receptor regulatory pathway.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D017292
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SnomedCT |
108556006, 372508002 |
LNC |
LP171393-4 |
English |
Doxazosin, Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, Doxazosin [Chemical/Ingredient], doxazosin (medication), alpha blockers doxazosin, doxazosin, DOXAZOSIN, Doxazosin (product), Doxazosin (substance) |
Swedish |
Doxazosin
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Czech |
doxazosin
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Finnish |
Doksatsosiini
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Russian |
DOKSAZOZIN, ДОКСАЗОЗИН |
Japanese |
ドキサゾシン, ドキサゾシンメシレート, メシル酸ドキサゾシン |
Spanish |
Doxazosina, Doxazosin, doxazosina (producto), doxazosina (sustancia), doxazosina |
Portuguese |
Doxazossina, Doxazosin, Doxazosina |
Polish |
Doksazosyna, Metylosulfonian doksazosyny |
French |
Doxazosine
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German |
Doxazosin
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Italian |
Dossazosina
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Ontology:
Minipress
(C0242447)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D011224
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English |
Pfizer Brand of Prazosin Hydrochloride, minipress, Minipress |
Ontology:
Hytrin
(C0591628)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C041226
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English |
Abbott Brand of Terazosin Hydrochloride, hytrin, hytrin bph, Hytrin, Hytrin BPH, Deflox, Flotrin, Heitrin, Hytrine |
Ontology:
Cardura
(C0678136)
Definition (MSH)
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Trade name in United States.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D017292
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English |
Carduran, cardura, carduran, Cardura, Cardular, Pfizer Brand of Doxazosin Mesylate, Zoxan |