II. Definitions
- Cerebrospinal Fluid
- Clear, colorless fluid produced in the Choroid plexus within the walls of the Cerebral Ventricles
- CSF typically contains no white or Red Blood Cells (WBCs or RBCs) and low levels of Protein
- CSF is produced in the Choroid plexus of fluid filled chambers known as ventricles
- Flows through the Cerebral Ventricles within the subarachnoid space
- Surrounds and protects the brain and spinal cord
- Clear, colorless fluid produced in the Choroid plexus within the walls of the Cerebral Ventricles
III. Physiology
-
Choroid Plexus: Formation of CSF
- Tufts of capillaries in Lateral Ventricles
- Produces CSF at 20 ml/hour (up to 500 ml/day)
- Pathway
- See Cerebral Ventricle for Cerebrospinal Flow
- CSF flows down Magendie and Luschka canals and via subarachnoid space around the brain and spinal cord
- CSF Reabsorption
- CSF reabsorption at the arachnoid villi and dural sinuses
- Drains into the internal Jugular Veins
- CSF Volume
- Total CSF in circulation: 140 ml
- Distribution
- Ventricles: 25 ml
- Subarachnoid space: 115 ml
IV. References
- Gilman (1989) Manter and Gatz Essentials of Neuroanatomy and Neurophysiology, Davis, p. 232-7
- Goldberg (2014) Clinical Neuroanatomy, p. 6-15
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| Definition (FMA) | Transudate contained in the subarachnoid space. |
| Definition (UWDA) | Transudate contained in the subarachnoid space. |
| Definition (NCI_NCI-GLOSS) | The fluid that flows in and around the hollow spaces of the brain and spinal cord, and between two of the meninges (the thin layers of tissue that cover and protect the brain and spinal cord). CSF is made by tissue called the choroid plexus in the ventricles (hollow spaces) in the brain. |
| Definition (NCI) | The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. |
| Definition (NCI_CDISC) | The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (NCI) |
| Definition (MSH) | A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES. |
| Definition (CSP) | clear colorless liquid secreted by the choroid plexus of the lateral, third, and fourth ventricles, and contained within the ventricular system of the brain and spinal cord and within the subarachnoid space. |
| Concepts | Body Substance (T031) |
| MSH | D002555 |
| SnomedCT | 65216001, 23889009 |
| HL7 | CSF |
| LNC | LP7156-5, LP36066-6, MTHU001311 |
| English | Cerebrospinal Fluid, Cerebrospinal Fluids, Fluid, Cerebrospinal, Fluids, Cerebrospinal, Spinal fluid, spinal fluid, CSF, Liquor cerebrospinalis, Cerebral Spinal Fluid, cerebrospinal fluid (CSF), Spinal fluid (substance), Cerebral spinal fluid, cerebrospinal fluid, FLUID, CEREBROSPINAL, CEREBROSPINAL FLUID, Cerebro Spinal Fluids, Fluids, Cerebro Spinal, Spinal Fluids, Cerebro, Cerebro Spinal Fluid, Fluid, Cerebro Spinal, Spinal Fluid, Cerebro, Cerebrospinal fluid, CSF - Cerebrospinal fluid, Cerebrospinal fluid (substance), Cerebrospinal fluid, NOS, Spinal Fluid |
| French | Liquide céphalorachidien, Liquide cérébro-spinal, Liquide céphalo-rachidien, Liquide cérébrospinal, LCS (Liquide CérébroSpinal), LCR (Liquide CéphaloRachidien) |
| Swedish | Cerebrospinalvätska |
| Czech | mozkomíšní mok, cerebrospinální likvor |
| Spanish | LCR - líquido cefalorraquídeo, LCR, líquido raquídeo (sustancia), líquido raquídeo, líquido cefalorraquídeo (sustancia), líquido cefalorraquídeo, Líquido Cefalorraquídeo |
| Finnish | Aivo-selkäydinneste |
| Russian | TSEREBROSPINAL'NAIA ZHIDKOST', SPINNOMOZGOVAIA ZHIDKOST', СПИННОМОЗГОВАЯ ЖИДКОСТЬ, ЦЕРЕБРОСПИНАЛЬНАЯ ЖИДКОСТЬ |
| Croatian | CEREBROSPINALNI LIKVOR |
| Latvian | Smadzeņu, muguras, šķidrums, Muguras smadzeņu šķidrums |
| Polish | Płyn mózgowo-rdzeniowy |
| Norwegian | Cerebrospinalvæske, Liquor cerebrospinalis |
| Portuguese | Liquor, Líquido Cefalorraquiano, Líquido Cerebrospinal, Líquido Cefalorraquidiano |
| German | Liquor cerebrospinalis, Zerebrospinalflüssigkeit |
| Italian | Liquor cefalorachidiano |
| Dutch | Cerebrospinale vloeistof, Liquor cerebrospinalis, Vloeistof, cerebrospinale |
Ontology: Nonspecific abnormal findings in cerebrospinal fluid (C0151583)
| Concepts | Finding (T033) |
| ICD9 | 792.0 |
| ICD10 | R83 , R83.9 |
| SnomedCT | 207335007, 158579002 |
| English | Nonspecific abnormal findings in cerebrospinal fluid, CSF ABNORMAL, Abnormal findings in cerebrospinal fluid, unspecified abnormal finding, Cerebrospinal fluid abnorm., Cerebrospinal fluid abnormality, [D]Cerebrospinal fluid abnormality (context-dependent category), [D]Cerebrospinal fluid abnorm., [D]Cerebrospinal fluid abnormality, Spinal fluid abnorm, Cerebrospinal fluid abnormal, CSF abnormal, CSF abnormal NOS, CSF abnormality NOS, Abn fnd-cerebrospinal fl, Abnormal findings in cerebrospinal fluid, abnormalities csf, cerebrospinal fluid abnormality, abnormal csf, [D]Cerebrospinal fluid abnormality (situation), cerebrospinal; abnormal fluid, cerebrospinal; fluid abnormal, fluid; abnormal, cerebrospinal, abnormal; fluid, cerebrospinal, abnormality; fluid, cerebrospinal, Cerebrospinal fluid abnormal NOS, Cerebrospinal fluid abnormality NOS |
| Dutch | CSV abnormaal, niet-specifieke abnormale bevindingen in cerebrospinaal vocht, CSV abnormaliteit NAO, cerebrospinaal vocht abnormaal, cerebrospinaal vocht abnormaal NAO, ruggenmerg vocht abnormaal, abnormaal; vloeistof, cerebrospinaal, afwijking; vloeistof, cerebrospinaal, cerebrospinaal; afwijking vloeistof, cerebrospinaal; vloeistof afwijkend, vloeistof; afwijkend, cerebrospinaal, Afwijkende bevindingen in cerebrospinale vloeistof; Niet gespecificeerde afwijkende bevinding, Afwijkende bevindingen in cerebrospinale vloeistof |
| French | LCR anormal SAI, Résultats anormaux non spécifiques de l'examen du liquide céphalo-rachidien, Anomalie du LCR SAI, Liquide céphalo-rachidien anormal, LCR anormal, Liquide rachidien anormal, ANOMALIE DU LCR |
| German | Liquoranomalie NNB, unspezifische anomale Befunde im Liquor, Liquor anomal, Liquor anomal NNB, Abnorme Liquorbefunde: Nicht naeher bezeichneter abnormer Befund, Abnorme Liquorbefunde, LIQUOR PATHOLOGISCH VERAENDERT |
| Italian | Liquido cerebrospinale anormale non specificato, Liquido cerebrospinale anormale, Alterazione del liquido cerebrospinale NAS, Reperti anormali non specifici nel liquido cerebrospinale, Liquido spinale anormale |
| Portuguese | LCR anormal, LCR anormal NE, Anomalia do LSR NE, Líquido cefalorraquidiano anormal, Dados anormais inespecíficos do LCR, ALTERACOES DO LIQUOR |
| Spanish | Líquido cefalorraquídeo anormal, LCR anormal, LCR anormal NEOM, Anormalidad del LCR NEOM, Hallazgos anormales no específicos en el líquido cefalorraquídeo, [D]anomalía del líquido cefalorraquídeo (categoría dependiente del contexto), Líquido raquídeo anormal, LCR ALTERADO, [D]anomalía del líquido cefalorraquídeo (situación), [D]anomalía del líquido cefalorraquídeo |
| Japanese | 髄液異常, 髄液の非特異的異常所見, ＣＳＦ異常ＮＯＳ, ＣＳＦ異常, ｽﾞｲｴｷﾉﾋﾄｸｲﾃｷｲｼﾞｮｳｼｮｹﾝ, 脊髄液異常, CSFｲｼﾞｮｳNOS, CSFｲｼﾞｮｳ, ｽﾞｲｴｷｲｼﾞｮｳ, ｾｷｽﾞｲｴｷｲｼﾞｮｳ |
| Czech | Nespecifické abnormální nálezy v mozkomíšním moku, Mozkomíšní mok abnormální, Abnormalita CSF NOS, Abnormální míšní mok, CSF abnormální, CSF abnormální NOS |
| Korean | 뇌척수액의 이상 소견 |
| Hungarian | Liquor kóros, Liquor kóros k.m.n., Gerincfolyadék kóros, Liquor-rendellenesség k.m.n., Nem specifikus kóros liquor leletek |
