II. Causes: Newborn (age <1 month)
- Vomiting in a newborn is abnormal until serious causes are excluded
- Gastrointestinal obstruction (Abdominal Distention, Unconsolable Infant, poor feeding, bilious or Projectile Vomiting)
- Intestinal Malrotation with Volvulus
- Presents with Bilious Emesis
- More than 50% of cases present in the first month of life
- Intestinal Atresia (including Duodenal Atresia)
- Typically presents while still in newborn nursery
- Meconium Ileus (Cystic Fibrosis)
- Hirschsprung's Disease
- Typically presents in first few days of life with delayed passage of meconium
- Delayed presentation may occur with Abdominal Distention, Vomiting, lethargy, Anorexia
- May also present with Hirschsprung-Associated Enterocolitis
- Pyloric Stenosis
- See below
- Incarcerated Inguinal Hernia
- Consider in both boys and girls
- Intestinal Malrotation with Volvulus
- Infection or Sepsis (fever, listless)
- Urinary Tract Infection
- Meningitis
- Bacteremia
- Ill appearing without infection
- Other benign causes
- Pediatric Reflux
- See below
- Nasal congestion
- See below
- Pediatric Reflux
III. Causes: Infants (age 1 month to 1 year)
- Mechanical gastrointestinal obstruction (Abdominal Distention, bilious or Projectile Vomiting)
- Incarcerated Hernia
- Intestinal Malrotation with Volvulus
- Pyloric Stenosis
- Age 3-6 week old (nearly always by 3 months), esp. in boys
- Nonbilious, projectile Emesis within minutes of feeding
- Intussusception
- Age 3 months to 3 years
- Paroxysms of intermittent severe Abdominal Pain (child may draw legs to Abdomen) and inconsolable
- Interspersed periods of pain resolution
- Associated with intractable Vomiting, lethargy
- Infection
- Viral Gastroenteritis
- See below
- Bacterial enteritis
- Acute Otitis Media
- Urinary Tract Infection
- Viral Gastroenteritis
- Other serious causes
- Nonaccidental Trauma with abusive Head Injury
- Unknown Ingestion
- Other non-serious causes
- Pediatric Reflux
- Most common cause of Vomiting in infants
- Consider pathologic reflux if weight loss, food aversion, persistent fussiness
- Nasal congestion
- Infants are obligate nose breathers
- May result in Emesis and Choking episodes
- Treat with frequent Nasal Saline and suctioning
- Pediatric Reflux
IV. Causes: Children (age >1 year)
- Infection
- Viral Gastroenteritis (see comments above)
- Diagnosis of exclusion, unless Vomiting followed by Diarrhea (often with exposure history)
- Consider alternative diagnosis with fever, significant Abdominal Pain, lethargy, toxicity
- Most common cause of Vomiting in Children over age 1 year
- Appendicitis (guarding, Rebound Tenderness, Rosving Sign, Psoas Sign)
- Urinary Tract Infection
- Viral Gastroenteritis (see comments above)
- Other serious causes
- Diabetic Ketoacidosis
- New onset Type 1 Diabetes Mellitus may present as intractable Vomiting, Dehydration
- Higher risk as presenting finding in age <4 years, lower socioeconomic status
- Presents with Vomiting, Abdominal Pain, weight loss, Polyuria, polydipsia, Tachycardia, Hypotension
- Testicular Torsion
- Ovarian Torsion
- Foreign Body Ingestion
- Nonaccidental Trauma
- Pediatric Blunt Abdominal Trauma
- Intussusception
- See Above
- Superior Mesenteric Artery Syndrome
- Duodenum constricted between superior Mesenteric Artery and abdominal aorta
- Rare, but increased risk in slender patients with weight loss (e.g. Anorexia Nervosa, Gastroenteritis)
- Presents as proximal Small Bowel Obstruction with Bilious Emesis, upper Abdominal Pain, early satiety
- Diabetic Ketoacidosis
- Other causes
- Migraine Headaches
- Exclude intracranial cause (thorough history and exam) when Migraine diagnosis has not been established
- Cyclical Vomiting Syndrome
- Recurrent Emesis episodes lasting hours to days in school age children
- Associated with Migraine Headaches and responds to Migraine Headache Management
- Gastroparesis
- Postprandial Nausea, Vomiting, distention, early satiety and Epigastric Pain
- Consider following viral illness (esp. Rotavirus), Anticholinergic or Opioid medications
- Consider in Diabetes Mellitus and neuromuscular disorders (e.g. Cerebral Palsy, Muscular Dystrophy)
- Migraine Headaches
V. Causes: Teens
- See Vomiting Causes
- See causes above
-
Pancreatitis
- Consider Medication Causes of Pancreatitis
- Consider Infections (e.g. mumps, Mycoplasma pneumonia)
- Consider Pediatric Blunt Abdominal Trauma
-
Cholecystitis
- Consider young presentations in Celiac Disease, Sickle Cell Anemia, spherocytosis, prolonged Parenteral nutrition
- Pregnancy
- Peptic Ulcer Disease
- Gastroesophageal Reflux disease or Esophagitis
- Unknown Ingestion
VI. Causes: Common
VII. Causes: Increased Intracranial Pressure
- See Brain Lesion in Children
- Meningitis
- Pseudotumor Cerebri
- Hydrocephalus
- Abusive Head Trauma of Infancy (previously Shaken Baby Syndrome)
- Metabolic Encephalopathy
- Brain Abscess
VIII. Causes: Metabolic
- See Inborn Errors of Metabolism
- Galactosemia
- High ammonia
- Congenital Adrenal Hyperplasia
- Phenylketonuria
- Organic acidemia
- Hypokalemia
- Hypermagnesemia
- Hypercalcemia
IX. Causes: Medications and Toxins
X. Causes: Infectious
XI. Causes: Anatomic malformation
- Pyloric Stenosis
- Intussusception
- Malrotation
- Volvulus
- Inguinal Hernia
- Intestinal adhesions
- Gastric web
- Esophageal atresia
- Intestinal Atresia
- Hirschsprung's Disease
- Annular Pancreas
- Imperforate anus
- Meconium ileus
- Small left colon
- Gastroschisis
- Omphalocele
- Prostaglandin-induced antral hypertrophy
- Gastroparesis
XII. Causes: Miscellaneous
- Obstructive uropathy
- Vascular anomaly
- Small Bowel Obstruction (esp. prior abdominal surgery, Inguinal Hernia)
- Necrotizing Enterocolitis (NEC)
- Protein-sensitive enterocolitis
- Peptic Ulcer Disease (Gastric or Duodenal Ulcer)
- Gastritis
- Esophagitis
- Appendicitis
- Meckel's Diverticulum
- Pseudo-obstruction
- Pregnancy (teens)
- Foreign Body Ingestion
- Ureterolithiasis
XIII. References
- (2017) Crit Dec Emerg Med 31(4): 19-25