Polyuria

Aka: Polyuria

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II. Definitions

  1. Polyuria
    1. Large volume of urine at increased frequency
    2. Formal definitions have included urine in excess of 3 Liters/day

III. Causes

  1. Primary Polydipsia
    1. See Isovolemic Hypoosmolar Hyponatremia
    2. Hypothalamus disorder
    3. Water Intoxication (Psychogenic Polydipsia)
    4. Medications (Thioridazine, Chlorpromazine, Anticholinergic Agents)
  2. Impaired conservation of renal water
    1. Diabetes Insipidus
      1. Central Diabetes Insipidus
      2. Nephrogenic Diabetes Insipidus (most common)
    2. Solute diuresis
      1. Glycosuria (Diabetes Mellitus)
      2. High Protein tube enteral feeding
      3. Urea infusion
      4. Mannitol infusion
      5. Chronic Renal Failure
      6. Radiographic contrast dye
    3. Natriuretic syndrome
      1. Salt-losing nephritis
      2. Acute Tubular Necrosis (Diuretic phase)
      3. Diuretics

IV. References

  1. Coe in Wilson (1991) Harrison's Internal Medicine, 12th ed, McGraw Hill, p. 275

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