II. Epidemiology
- Since Rotavirus Vaccine was initiated in 2006 in U.S., cases have fallen as much as 90%
- Prior to Rotavirus Vaccine starting in 2006, was the most common cause of Acute Infectious Diarrhea in the U.S.
- Accounted for 35% of child hospitalizations for Diarrhea
- Hospitalizations: 55,000 to 70,000 per year in United States
- Mortality: 20-60 deaths per year in United States
- Worldwide Rotavirus still kills more than 400,000 children under age 5 years old
- Peak ages affected: 6 months to 2 years old
- Uncommon under age 6 months or over age 4 years
- Infection peaks in March (mid-January to late May)
III. Pathophysiology
- Antibody to Rotavirus is protective
- Self limited Infection
- Transmission: Fecal-oral route
- Incubation: 1-3 days
V. Prevention
- Careful Hand Washing
- See Rotavirus Vaccine
- Limited use due to Intussusception risk
VI. Resources
- CDC Rotavirus
VII. References
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Related Studies
Definition (NCI_CDISC) | Any viral organism that can be assigned to the genus Rotavirus. |
Definition (NCI) | A genus of double stranded RNA viruses that carry 11 unique double helix molecules of RNA that encode one or two proteins each. The RNA is surrounded by a three-layered icosahedral protein capsid. Viral particles are up to 76.5 nm in diameter and are not enveloped. |
Definition (MSH) | A genus of REOVIRIDAE, causing acute gastroenteritis in BIRDS and MAMMALS, including humans. Transmission is horizontal and by environmental contamination. Seven species (Rotaviruses A thru G) are recognized. |
Definition (CSP) | 6 serogroups described; group A occurs in mammals and birds; group B in humans, pigs, cattle, sheep and rats; group C in pigs and rarely humans; groups D and F in poultry; and group E in pigs. |
Concepts | Virus (T005) |
MSH | D012401 |
SnomedCT | 70614005, 417542000 |
LNC | LP14844-2, MTHU002054 |
English | Rotaviruses, Genus: Rotavirus, rotavirus, rotaviruses, Rotavirus, NOS, Rotavirus (organism), Rotavirus, Genus Rotavirus (organism), Genus Rotavirus, ROTAVIRUS |
Swedish | Rotavirus |
Spanish | rotavirus (organismo), Rotavirus, género: Rotavirus, rotavirus, Rotavirus, SAI, género Rotavirus (organismo), género Rotavirus |
Czech | Rotavirus |
Finnish | Rotavirus |
Russian | NEONATAL'NOI DIAREI TELIAT VIRUS, ROTAVIRUS, НЕОНАТАЛЬНОЙ ДИАРЕИ ТЕЛЯТ ВИРУС, РОТАВИРУС |
Croatian | ROTAVIRUS |
Polish | Rotawirusy |
French | Rotavirus |
German | Rotavirus |
Italian | Rotavirus |
Dutch | Rotavirus, Virus, Rota- |
Portuguese | Rotavirus |