II. Epidemiology

  1. Since Rotavirus Vaccine was initiated in 2006 in U.S., cases have fallen as much as 90%
  2. Prior to Rotavirus Vaccine starting in 2006, was the most common cause of Acute Infectious Diarrhea in the U.S.
    1. Accounted for 35% of child hospitalizations for Diarrhea
    2. Hospitalizations: 55,000 to 70,000 per year in United States
    3. Mortality: 20-60 deaths per year in United States
  3. Worldwide Rotavirus still kills more than 400,000 children under age 5 years old
  4. Peak ages affected: 6 months to 2 years old
    1. Uncommon under age 6 months or over age 4 years
  5. Infection peaks in March (mid-January to late May)

III. Pathophysiology

  1. Antibody to Rotavirus is protective
  2. Self limited Infection
  3. Transmission: Fecal-oral route
  4. Incubation: 1-3 days

IV. Symptoms

  1. Emesis for 3 days
  2. Severe Watery Diarrhea for 3-8 days
  3. Fever
  4. Upper respiratory symptoms

V. Prevention

  1. Careful hand washing
  2. See Rotavirus Vaccine
    1. Limited use due to Intussusception risk

VI. Resources

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Ontology: Rotavirus (C0035870)

Definition (NCI_CDISC) Any viral organism that can be assigned to the genus Rotavirus.
Definition (NCI) A genus of double stranded RNA viruses that carry 11 unique double helix molecules of RNA that encode one or two proteins each. The RNA is surrounded by a three-layered icosahedral protein capsid. Viral particles are up to 76.5 nm in diameter and are not enveloped.
Definition (MSH) A genus of REOVIRIDAE, causing acute gastroenteritis in BIRDS and MAMMALS, including humans. Transmission is horizontal and by environmental contamination. Seven species (Rotaviruses A thru G) are recognized.
Definition (CSP) 6 serogroups described; group A occurs in mammals and birds; group B in humans, pigs, cattle, sheep and rats; group C in pigs and rarely humans; groups D and F in poultry; and group E in pigs.
Concepts Virus (T005)
MSH D012401
SnomedCT 70614005, 417542000
LNC LP14844-2, MTHU002054
English Rotaviruses, Genus: Rotavirus, rotavirus, rotaviruses, Rotavirus, NOS, Rotavirus (organism), Rotavirus, Genus Rotavirus (organism), Genus Rotavirus, ROTAVIRUS
Swedish Rotavirus
Spanish rotavirus (organismo), Rotavirus, género: Rotavirus, rotavirus, Rotavirus, SAI, género Rotavirus (organismo), género Rotavirus
Czech Rotavirus
Finnish Rotavirus
Polish Rotawirusy
French Rotavirus
German Rotavirus
Italian Rotavirus
Dutch Rotavirus, Virus, Rota-
Portuguese Rotavirus